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Int. J. Mol. Sci. 2012, 13(8), 9971-9979; doi:10.3390/ijms13089971

Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

Department of Food Science and Engineering, Jilin University, Changchun 130021, China
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China
College of Chemistry, Jilin University, Changchun 130023, China
Author to whom correspondence should be addressed.
Received: 23 May 2012 / Revised: 30 June 2012 / Accepted: 2 August 2012 / Published: 10 August 2012
(This article belongs to the Special Issue Enzyme Optimization and Immobilization)
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Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
Keywords: triptorelin lactate; lipase; enzyme activity; esterification triptorelin lactate; lipase; enzyme activity; esterification
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhuang, H.; Wang, Z.; Wang, J.; Zhang, H.; Xun, E.; Chen, G.; Yue, H.; Tang, N.; Wang, L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. Int. J. Mol. Sci. 2012, 13, 9971-9979.

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