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Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
Department of Food Science and Engineering, Jilin University, Changchun 130021, China
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China
College of Chemistry, Jilin University, Changchun 130023, China
* Author to whom correspondence should be addressed.
Received: 23 May 2012; in revised form: 30 June 2012 / Accepted: 2 August 2012 / Published: 10 August 2012
Abstract: Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
Keywords: triptorelin lactate; lipase; enzyme activity; esterification
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MDPI and ACS Style
Zhuang, H.; Wang, Z.; Wang, J.; Zhang, H.; Xun, E.; Chen, G.; Yue, H.; Tang, N.; Wang, L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. Int. J. Mol. Sci. 2012, 13, 9971-9979.
Zhuang H, Wang Z, Wang J, Zhang H, Xun E, Chen G, Yue H, Tang N, Wang L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. International Journal of Molecular Sciences. 2012; 13(8):9971-9979.
Zhuang, Hong; Wang, Zhi; Wang, Jiaxin; Zhang, Hong; Xun, Erna; Chen, Ge; Yue, Hong; Tang, Ning; Wang, Lei. 2012. "Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media." Int. J. Mol. Sci. 13, no. 8: 9971-9979.