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Int. J. Mol. Sci. 2012, 13(8), 9971-9979; doi:10.3390/ijms13089971
Article

Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

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Received: 23 May 2012; in revised form: 30 June 2012 / Accepted: 2 August 2012 / Published: 10 August 2012
(This article belongs to the Special Issue Enzyme Optimization and Immobilization)
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Abstract: Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
Keywords: triptorelin lactate; lipase; enzyme activity; esterification triptorelin lactate; lipase; enzyme activity; esterification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhuang, H.; Wang, Z.; Wang, J.; Zhang, H.; Xun, E.; Chen, G.; Yue, H.; Tang, N.; Wang, L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. Int. J. Mol. Sci. 2012, 13, 9971-9979.

AMA Style

Zhuang H, Wang Z, Wang J, Zhang H, Xun E, Chen G, Yue H, Tang N, Wang L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. International Journal of Molecular Sciences. 2012; 13(8):9971-9979.

Chicago/Turabian Style

Zhuang, Hong; Wang, Zhi; Wang, Jiaxin; Zhang, Hong; Xun, Erna; Chen, Ge; Yue, Hong; Tang, Ning; Wang, Lei. 2012. "Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media." Int. J. Mol. Sci. 13, no. 8: 9971-9979.



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