Next Article in Journal
Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma
Next Article in Special Issue
New Biofuel Integrating Glycerol into Its Composition Through the Use of Covalent Immobilized Pig Pancreatic Lipase
Previous Article in Journal
Chick Chorioallantoic Membrane (CAM) Assay as an In Vivo Model to Study the Effect of Newly Identified Molecules on Ovarian Cancer Invasion and Metastasis
Previous Article in Special Issue
Enzymatic Properties and Mutational Studies of Chalcone Synthase from Physcomitrella patens
Int. J. Mol. Sci. 2012, 13(8), 9971-9979; doi:10.3390/ijms13089971
Article

Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

1
, 2
, 2
, 2,3
, 2
, 2
, 2
, 1
 and 2,*
1 Department of Food Science and Engineering, Jilin University, Changchun 130021, China 2 Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China 3 College of Chemistry, Jilin University, Changchun 130023, China
* Author to whom correspondence should be addressed.
Received: 23 May 2012 / Revised: 30 June 2012 / Accepted: 2 August 2012 / Published: 10 August 2012
(This article belongs to the Special Issue Enzyme Optimization and Immobilization)
View Full-Text   |   Download PDF [129 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
Keywords: triptorelin lactate; lipase; enzyme activity; esterification triptorelin lactate; lipase; enzyme activity; esterification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Zhuang, H.; Wang, Z.; Wang, J.; Zhang, H.; Xun, E.; Chen, G.; Yue, H.; Tang, N.; Wang, L. Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media. Int. J. Mol. Sci. 2012, 13, 9971-9979.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert