Next Article in Journal
Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy
Next Article in Special Issue
Determination and Analysis of Ustiloxins A and B by LC-ESI-MS and HPLC in False Smut Balls of Rice
Previous Article in Journal
Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer
Previous Article in Special Issue
Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization
Int. J. Mol. Sci. 2012, 13(8), 9642-9648; doi:10.3390/ijms13089642
Communication

Neuroprotective Effects of Triterpene Glycosides from Glycine max against Glutamate Induced Toxicity in Primary Cultured Rat Cortical Cells

*  and
Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, Busan 604-714, Korea
* Author to whom correspondence should be addressed.
Received: 7 June 2012 / Revised: 16 July 2012 / Accepted: 23 July 2012 / Published: 2 August 2012
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)
View Full-Text   |   Download PDF [246 KB, uploaded 19 June 2014]   |   Browse Figure

Abstract

To examine the neuroprotective effects of Glycine max, we tested its protection against the glutamate-induced toxicity in primary cortical cultured neurons. In order to clarify the neuroprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. From such fractionation, two triterpene glycosides, 3-O-[α-L-rhamnopyranosyl(1-2)-β-D-glucopyranosyl(1-2)-β-D-glucuronopyranosyl]olean-12-en-3β,22β,24-triol (1) and 3-O-[β-D-glucopyranosyl(1-2)-β-D-galactopyranosyl(1-2)-β-D-glucuronopyranosyl]olean-12-en-3β,22β,24-triol (2) were isolated with the methanol extracts with of air-dried Glycine max. Among these compounds, compound 2 exhibited significant neuroprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50% at concentrations ranging from 0.1 μM to 10 μM. Therefore, the neuroprotective effect of Glycine max might be due to the inhibition of glutamate-induced toxicity by triterpene glycosides.
Keywords: Glycine max; glutamate-induced toxicity; neuroprotective; triterpene glycosides Glycine max; glutamate-induced toxicity; neuroprotective; triterpene glycosides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Moon, H.-I.; Lee, J.-H. Neuroprotective Effects of Triterpene Glycosides from Glycine max against Glutamate Induced Toxicity in Primary Cultured Rat Cortical Cells. Int. J. Mol. Sci. 2012, 13, 9642-9648.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert