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Int. J. Mol. Sci. 2012, 13(8), 10461-10477; doi:10.3390/ijms130810461
Review

Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer

1,2
, 1,3
 and 1,*
Received: 30 June 2012; in revised form: 3 August 2012 / Accepted: 16 August 2012 / Published: 21 August 2012
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer 2012)
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Abstract: Transforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of physiological and pathological conditions including diabetes, corneal dystrophy and tumorigenesis. Many reports indicate that βig-H3 functions as a tumor suppressor. Loss of βig-H3 expression has been described in several cancers including ovarian cancer and promoter hypermethylation has been identified as an important mechanism for the silencing of the TGFBI gene. Our recent findings that βig-H3 is down-regulated in ovarian cancer and that high concentrations of βig-H3 can induce ovarian cancer cell death support a tumor suppressor role. However, there is also convincing data in the literature reporting a tumor-promoting role for βig-H3. We have shown βig-H3 to be abundantly expressed by peritoneal cells and increase the metastatic potential of ovarian cancer cells by promoting cell motility, invasion, and adhesion to peritoneal cells. Our findings suggest that βig-H3 has dual functions and can act both as a tumor suppressor or tumor promoter depending on the tumor microenvironment. This article reviews the current understanding of βig-H3 function in cancer cells with particular focus on ovarian cancer.
Keywords: ovarian cancer; extracellular matrix; TGFBI; tumor suppressor; invasion; adhesion; metastasis ovarian cancer; extracellular matrix; TGFBI; tumor suppressor; invasion; adhesion; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ween, M.P.; Oehler, M.K.; Ricciardelli, C. Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer. Int. J. Mol. Sci. 2012, 13, 10461-10477.

AMA Style

Ween MP, Oehler MK, Ricciardelli C. Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer. International Journal of Molecular Sciences. 2012; 13(8):10461-10477.

Chicago/Turabian Style

Ween, Miranda P.; Oehler, Martin K.; Ricciardelli, Carmela. 2012. "Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer." Int. J. Mol. Sci. 13, no. 8: 10461-10477.


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