Int. J. Mol. Sci. 2012, 13(8), 10387-10400; doi:10.3390/ijms130810387
Article

MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis

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Received: 19 June 2012; in revised form: 23 July 2012 / Accepted: 9 August 2012 / Published: 21 August 2012
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer 2012)
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Abstract: Mucin 16 (MUC16) is a type I transmembrane protein, the extracellular portion of which is shed after proteolytic degradation and is denoted as CA125 antigen, a well known tumor marker for ovarian cancer. Regarding its polypeptide and glycan structures, as yet there is no detailed insight into their heterogeneity and ligand properties, which may greatly influence its function and biomarker potential. This study was aimed at obtaining further insight into the biological capacity of MUC16/CA125, using in silico analysis of corresponding mucin sequences, including similarity searches as well as GO (gene ontology)-based function prediction. The results obtained pointed to the similarities within extracellular serine/threonine rich regions of MUC16 to sequences of proteins expressed in evolutionary distant taxa, all having in common an annotated role in adhesion-related processes. Specifically, a homology to conserved domains from the family of herpesvirus major outer envelope protein (BLLF1) was found. In addition, the possible involvement of MUC16/CA125 in carbohydrate-binding interactions or cellular transport of protein/ion was suggested.
Keywords: MUC16; CA125; in silico; conserved domain; adhesion; herpesvirus; yeast; sugar-binding; ion transport
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jankovic, M.; Mitic, N. MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis. Int. J. Mol. Sci. 2012, 13, 10387-10400.

AMA Style

Jankovic M, Mitic N. MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis. International Journal of Molecular Sciences. 2012; 13(8):10387-10400.

Chicago/Turabian Style

Jankovic, Miroslava; Mitic, Ninoslav. 2012. "MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis." Int. J. Mol. Sci. 13, no. 8: 10387-10400.


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