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Int. J. Mol. Sci. 2012, 13(8), 10387-10400; doi:10.3390/ijms130810387

MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis

Department for Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy-INEP, University of Belgrade, Banatska 31 b, Belgrade 11080, Serbia
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Received: 19 June 2012 / Revised: 23 July 2012 / Accepted: 9 August 2012 / Published: 21 August 2012
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer 2012)
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Abstract

Mucin 16 (MUC16) is a type I transmembrane protein, the extracellular portion of which is shed after proteolytic degradation and is denoted as CA125 antigen, a well known tumor marker for ovarian cancer. Regarding its polypeptide and glycan structures, as yet there is no detailed insight into their heterogeneity and ligand properties, which may greatly influence its function and biomarker potential. This study was aimed at obtaining further insight into the biological capacity of MUC16/CA125, using in silico analysis of corresponding mucin sequences, including similarity searches as well as GO (gene ontology)-based function prediction. The results obtained pointed to the similarities within extracellular serine/threonine rich regions of MUC16 to sequences of proteins expressed in evolutionary distant taxa, all having in common an annotated role in adhesion-related processes. Specifically, a homology to conserved domains from the family of herpesvirus major outer envelope protein (BLLF1) was found. In addition, the possible involvement of MUC16/CA125 in carbohydrate-binding interactions or cellular transport of protein/ion was suggested. View Full-Text
Keywords: MUC16; CA125; in silico; conserved domain; adhesion; herpesvirus; yeast; sugar-binding; ion transport MUC16; CA125; in silico; conserved domain; adhesion; herpesvirus; yeast; sugar-binding; ion transport
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jankovic, M.; Mitic, N. MUC16/CA125 in the Context of Modular Proteins with an Annotated Role in Adhesion-Related Processes: In Silico Analysis. Int. J. Mol. Sci. 2012, 13, 10387-10400.

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