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Int. J. Mol. Sci. 2012, 13(8), 10424-10431; doi:10.3390/ijms130810424

An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell

1 Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China 2 Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China 3 Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
* Author to whom correspondence should be addressed.
Received: 15 May 2012 / Revised: 27 June 2012 / Accepted: 9 August 2012 / Published: 21 August 2012
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This paper reports a method for electrical communication between the inner part of cells and an electrode with the help of iRGD peptide. Due to the enhancement of the cell penetration caused by iRGD peptide, DNA molecules, previously modified on a gold electrode surface, can be easily transfected into the cells. At the same time, doxorubicin, an anticancer drug, can also be transfected into cells with high penetration. Consequently, doxorubicin binds to DNA chains through electrostatic interaction, and the redox reaction is transferred out of the cell across the cell membrane. As a result, this work may provide a novel way to get information from inside of cells.
Keywords: iRGD; cell penetration; doxorubicin; cell adhesion; electrochemistry iRGD; cell penetration; doxorubicin; cell adhesion; electrochemistry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ning, L.; Li, X.; Ding, X.; Yin, Y.; Li, G. An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell. Int. J. Mol. Sci. 2012, 13, 10424-10431.

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