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Int. J. Mol. Sci. 2012, 13(8), 10432-10440; doi:10.3390/ijms130810432
Article

An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

1,†
,
2
,
1
,
3,†
 and
1,4,5,*
1 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 4 Department of Pharmacy, China Medical University, Taichung 401, Taiwan 5 Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 401, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 June 2012 / Revised: 10 August 2012 / Accepted: 16 August 2012 / Published: 21 August 2012
(This article belongs to the Section Green Chemistry)
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Abstract

A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.
Keywords: Antrodia camphorata; benzocamphorin F; anti-inflammatory Antrodia camphorata; benzocamphorin F; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Liao, Y.-R.; Kuo, P.-C.; Liang, J.-W.; Shen, Y.-C.; Wu, T.-S. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity. Int. J. Mol. Sci. 2012, 13, 10432-10440.

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