Int. J. Mol. Sci. 2012, 13(8), 10432-10440; doi:10.3390/ijms130810432
Article

An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

Yu-Ren Liao 1,† email, Ping-Chung Kuo 2 email, Jun-Weil Liang 1 email, Yuh-Chiang Shen 3,† email and Tian-Shung Wu 1,4,5,* email
1 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 4 Department of Pharmacy, China Medical University, Taichung 401, Taiwan 5 Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 401, Taiwan † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 June 2012; in revised form: 10 August 2012 / Accepted: 16 August 2012 / Published: 21 August 2012
(This article belongs to the Section Green Chemistry)
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Abstract: A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.
Keywords: Antrodia camphorata; benzocamphorin F; anti-inflammatory

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Cite This Article

MDPI and ACS Style

Liao, Y.-R.; Kuo, P.-C.; Liang, J.-W.; Shen, Y.-C.; Wu, T.-S. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity. Int. J. Mol. Sci. 2012, 13, 10432-10440.

AMA Style

Liao Y-R, Kuo P-C, Liang J-W, Shen Y-C, Wu T-S. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2012; 13(8):10432-10440.

Chicago/Turabian Style

Liao, Yu-Ren; Kuo, Ping-Chung; Liang, Jun-Weil; Shen, Yuh-Chiang; Wu, Tian-Shung. 2012. "An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity." Int. J. Mol. Sci. 13, no. 8: 10432-10440.

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