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Int. J. Mol. Sci. 2012, 13(8), 10432-10440; doi:10.3390/ijms130810432
Article

An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

1,†
,
2
,
1
,
3,†
 and
1,4,5,*
Received: 26 June 2012 / Revised: 10 August 2012 / Accepted: 16 August 2012 / Published: 21 August 2012
(This article belongs to the Section Green Chemistry)
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Abstract

A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.
Keywords: Antrodia camphorata; benzocamphorin F; anti-inflammatory Antrodia camphorata; benzocamphorin F; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liao, Y.-R.; Kuo, P.-C.; Liang, J.-W.; Shen, Y.-C.; Wu, T.-S. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity. Int. J. Mol. Sci. 2012, 13, 10432-10440.

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