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Int. J. Mol. Sci. 2012, 13(8), 10432-10440; doi:10.3390/ijms130810432

An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

1 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 2 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 3 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 4 Department of Pharmacy, China Medical University, Taichung 401, Taiwan 5 Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 401, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 June 2012 / Revised: 10 August 2012 / Accepted: 16 August 2012 / Published: 21 August 2012
(This article belongs to the Section Green Chemistry)
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A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.
Keywords: Antrodia camphorata; benzocamphorin F; anti-inflammatory Antrodia camphorata; benzocamphorin F; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liao, Y.-R.; Kuo, P.-C.; Liang, J.-W.; Shen, Y.-C.; Wu, T.-S. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity. Int. J. Mol. Sci. 2012, 13, 10432-10440.

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