Int. J. Mol. Sci. 2012, 13(8), 10229-10235; doi:10.3390/ijms130810229
Article

Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

Received: 10 July 2012; in revised form: 1 August 2012 / Accepted: 6 August 2012 / Published: 16 August 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.
Keywords: osteoprogenitor; bone marrow stromal cell; mesenchymal stem cell; transplantation; tissue reconstruction
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MDPI and ACS Style

Itoh, S.; Matsushita, K.; Ikeda, S.; Yamamoto, Y.; Yamauchi, Y.; Yoshioka, S.; Yamamoto, R.; Ebisu, S.; Hayashi, M.; Aubin, J.E. Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors. Int. J. Mol. Sci. 2012, 13, 10229-10235.

AMA Style

Itoh S, Matsushita K, Ikeda S, Yamamoto Y, Yamauchi Y, Yoshioka S, Yamamoto R, Ebisu S, Hayashi M, Aubin JE. Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors. International Journal of Molecular Sciences. 2012; 13(8):10229-10235.

Chicago/Turabian Style

Itoh, Shousaku; Matsushita, Kenta; Ikeda, Shun; Yamamoto, Yumiko; Yamauchi, Yukako; Yoshioka, Seisuke; Yamamoto, Reiko; Ebisu, Shigeyuki; Hayashi, Mikako; Aubin, Jane E. 2012. "Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors." Int. J. Mol. Sci. 13, no. 8: 10229-10235.

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