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Int. J. Mol. Sci. 2012, 13(8), 10229-10235; doi:10.3390/ijms130810229

Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

1
Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8, Yamada-oka Suita, Osaka 565-0871, Japan
2
Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Room 4245, Medical Sciences Building, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada
*
Author to whom correspondence should be addressed.
Received: 10 July 2012 / Revised: 1 August 2012 / Accepted: 6 August 2012 / Published: 16 August 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.
Keywords: osteoprogenitor; bone marrow stromal cell; mesenchymal stem cell; transplantation; tissue reconstruction osteoprogenitor; bone marrow stromal cell; mesenchymal stem cell; transplantation; tissue reconstruction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Itoh, S.; Matsushita, K.; Ikeda, S.; Yamamoto, Y.; Yamauchi, Y.; Yoshioka, S.; Yamamoto, R.; Ebisu, S.; Hayashi, M.; Aubin, J.E. Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors. Int. J. Mol. Sci. 2012, 13, 10229-10235.

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