Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Morphology
2.2. FTIR Analysis
2.3. TG Analysis
2.4. Powder X-ray Diffraction (XRD)
2.5. Solubility and Dissolution Rate
2.6. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) Radical-Scavenging Activity
3. Experimental Section
3.1. Materials
3.2. Preparation of Micronized Taxifolin Powder by SAS
3.3. Scanning Electron Microscopy (SEM)
3.4. Fourier Transforms Infrared Spectroscopy (FTIR)
3.5. Thermal Gravimetric Analysis (TG)
3.6. X-ray Powder Diffraction (XRD)
3.7. BET Specific Surface Area Measurement
3.8. Dissolution Test
3.9. DPPH Assay
3.10. Statistical Analysis
4. Conclusions
Acknowledgments
References
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Run | Pressure MPa | Temperature °C | Concentration mg/mL | Flow rate mL/min | Length μm | Width μm | Morphology |
---|---|---|---|---|---|---|---|
1 | 20 | 35 | 10 | 4 | 5–30 | 1.2–3.6 | Needle-like |
2 | 20 | 45 | 10 | 4 | 20–100 | 2.0–3.4 | Needle-like |
3 | 20 | 55 | 10 | 4 | 30–150 | 20.-3.6 | Long needles |
4 | 20 | 65 | 10 | 4 | 40–200 | 1.4–4.4 | Long needles |
5 | 10 | 35 | 10 | 4 | 10–300 | 2.5–3.2 | Long needles |
6 | 15 | 35 | 10 | 4 | 10–100 | 1.6–2.7 | Needle-like |
7 | 25 | 35 | 10 | 4 | 2–10 | 0.7–1.2 | Needle-like |
8 | 25 | 35 | 10 | 3 | 5–9 | 1.2–1.6 | Needle-like |
9 | 25 | 35 | 10 | 5 | 6–10 | 1.2–1.5 | Needle-like |
10 | 25 | 35 | 10 | 6 | 9–11 | 1.1–1.3 | Needle-like |
11 | 25 | 35 | 5 | 3 | 2–11 | 1.1–1.2 | Needle-like |
12 | 25 | 35 | 15 | 3 | 13–18 | 1.4–2.6 | Rod-like shape |
13 | 25 | 35 | 20 | 3 | 24–29 | 2.4–4.6 | Long rod-like shape |
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Zu, S.; Yang, L.; Huang, J.; Ma, C.; Wang, W.; Zhao, C.; Zu, Y. Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity. Int. J. Mol. Sci. 2012, 13, 8869-8881. https://doi.org/10.3390/ijms13078869
Zu S, Yang L, Huang J, Ma C, Wang W, Zhao C, Zu Y. Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity. International Journal of Molecular Sciences. 2012; 13(7):8869-8881. https://doi.org/10.3390/ijms13078869
Chicago/Turabian StyleZu, Shuchong, Lei Yang, Jinming Huang, Chunhui Ma, Wenjie Wang, Chunjian Zhao, and Yuangang Zu. 2012. "Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity" International Journal of Molecular Sciences 13, no. 7: 8869-8881. https://doi.org/10.3390/ijms13078869