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Int. J. Mol. Sci. 2012, 13(7), 8869-8881; doi:10.3390/ijms13078869
Article

Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity

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State Engineering Laboratory for Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, China
* Authors to whom correspondence should be addressed.
Received: 4 June 2012 / Revised: 29 June 2012 / Accepted: 3 July 2012 / Published: 16 July 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (35–65 °C), pressure (10–25 MPa), solution flow rate (3–6 mL/min) and concentration of the liquid solution (5–20 mg/mL) on the precipitate crystals were investigated. With a lower temperature, a stronger pressure and a lower concentration of the liquid solution, the size of crystals decreased. The precipitation temperature, pressure and concentration of taxifolin solution had a significant effect. However, the solution flow rate had a negligible effect. It was concluded that the physicochemical properties and dissolution rate of crystalline taxifolin could be improved by physical modification such as particle size reduction using the supercritical antisolvent (SAS) process. Further, the SAS process was a powerful methodology for improving the physicochemical properties and radical scavenging activity of taxifolin.
Keywords: taxifolin; micronization; supercritical antisolvent; dissolution rate; radical scavenging activity; Larix gmelinii taxifolin; micronization; supercritical antisolvent; dissolution rate; radical scavenging activity; Larix gmelinii
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zu, S.; Yang, L.; Huang, J.; Ma, C.; Wang, W.; Zhao, C.; Zu, Y. Micronization of Taxifolin by Supercritical Antisolvent Process and Evaluation of Radical Scavenging Activity. Int. J. Mol. Sci. 2012, 13, 8869-8881.

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