Open AccessThis article is
- freely available
Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics
Department of Vegetal Biochemistry and Molecular Biology, Faculty of Chemistry, University of Seville, Apartado 1203, Sevilla 41071, Spain
* Author to whom correspondence should be addressed.
Received: 16 May 2012; in revised form: 18 June 2012 / Accepted: 19 June 2012 / Published: 28 June 2012
Abstract: Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N2 fixation, photorespiration or asparagine breakdown. A small gene family is encoding for different cytosolic (GS1) or plastidic (GS2) isoforms in legumes. We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production. Functional genomic analysis using GS2-minus mutant reveals the key role of GS2 in the metabolic control of the plants and, more particularly, in carbon metabolism.
Keywords: glutamine synthetase; Lotus japonicus; functional genomics; nitrogen metabolism
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Betti, M.; García-Calderón, M.; Pérez-Delgado, C.M.; Credali, A.; Estivill, G.; Galván, F.; Vega, J.M.; Márquez, A.J. Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics. Int. J. Mol. Sci. 2012, 13, 7994-8024.
Betti M, García-Calderón M, Pérez-Delgado CM, Credali A, Estivill G, Galván F, Vega JM, Márquez AJ. Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics. International Journal of Molecular Sciences. 2012; 13(7):7994-8024.
Betti, Marco; García-Calderón, Margarita; Pérez-Delgado, Carmen M.; Credali, Alfredo; Estivill, Guillermo; Galván, Francisco; Vega, José M.; Márquez, Antonio J. 2012. "Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics." Int. J. Mol. Sci. 13, no. 7: 7994-8024.