Int. J. Mol. Sci. 2012, 13(7), 7994-8024; doi:10.3390/ijms13077994
Review

Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics

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Received: 16 May 2012; in revised form: 18 June 2012 / Accepted: 19 June 2012 / Published: 28 June 2012
(This article belongs to the Special Issue Advances in Molecular Plant Biology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N2 fixation, photorespiration or asparagine breakdown. A small gene family is encoding for different cytosolic (GS1) or plastidic (GS2) isoforms in legumes. We summarize here the recent advances carried out concerning the quaternary structure of GS, as well as the functional relationship existing between GS2 and processes such as nodulation, photorespiration and water stress, in this latter case by means of proline production. Functional genomic analysis using GS2-minus mutant reveals the key role of GS2 in the metabolic control of the plants and, more particularly, in carbon metabolism.
Keywords: glutamine synthetase; Lotus japonicus; functional genomics; nitrogen metabolism
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MDPI and ACS Style

Betti, M.; García-Calderón, M.; Pérez-Delgado, C.M.; Credali, A.; Estivill, G.; Galván, F.; Vega, J.M.; Márquez, A.J. Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics. Int. J. Mol. Sci. 2012, 13, 7994-8024.

AMA Style

Betti M, García-Calderón M, Pérez-Delgado CM, Credali A, Estivill G, Galván F, Vega JM, Márquez AJ. Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics. International Journal of Molecular Sciences. 2012; 13(7):7994-8024.

Chicago/Turabian Style

Betti, Marco; García-Calderón, Margarita; Pérez-Delgado, Carmen M.; Credali, Alfredo; Estivill, Guillermo; Galván, Francisco; Vega, José M.; Márquez, Antonio J. 2012. "Glutamine Synthetase in Legumes: Recent Advances in Enzyme Structure and Functional Genomics." Int. J. Mol. Sci. 13, no. 7: 7994-8024.

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