Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke
Abstract
:1. Introduction
1.1. Patient Numbers and Current Methods of Care for Stroke
1.2. Dietary Supplementation and Neurogenesis
1.3. Recent Studies on Diet Supplementation Therapy in Ischemic Injury Models
1.4. Significance and Product Development
2. Preclinical Studies
2.1. NT-020 Attenuates Stroke-Induced Behavioral Deficits
2.2. NT-020 Reduces Stroke-Induced Cerebral Infarction
2.3. NT-020 Induces Cell Proliferation in Stroke Brain
2.4. NT-020 Promotes Neurogenesis in Stroke Brain
3. Caveats to Consider for Translational Research of NT-020
4. Conclusions
- Disclosure StatementP.C. Bickford is a co-founder and C.V. Borlongan is a consultant of Natura Therapeutics.
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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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Kaneko, Y.; Cortes, L.; Sanberg, C.; Acosta, S.; Bickford, P.C.; Borlongan, C.V. Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke. Int. J. Mol. Sci. 2012, 13, 7424-7444. https://doi.org/10.3390/ijms13067424
Kaneko Y, Cortes L, Sanberg C, Acosta S, Bickford PC, Borlongan CV. Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke. International Journal of Molecular Sciences. 2012; 13(6):7424-7444. https://doi.org/10.3390/ijms13067424
Chicago/Turabian StyleKaneko, Yuji, Lourdes Cortes, Cyndy Sanberg, Sandra Acosta, Paula C. Bickford, and Cesar V. Borlongan. 2012. "Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke" International Journal of Molecular Sciences 13, no. 6: 7424-7444. https://doi.org/10.3390/ijms13067424