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Evaluation of the Antioxidant Capacity of Synthesized Coumarins
Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil
Institute of Chemistry, Federal University of Rio de Janeiro, UFRJ, Bloco A, Cidade Universitária, 21941-909, Rio de Janeiro, RJ, Brazil
Post-Graduate Program in Physiological Sciences, Comparative Animal Physiology, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Av Itália km 8 s/n, 96201-900, Rio Grande, RS, Brazil
Institute of Chemistry, Universidade Federal Fluminense, UFF, Outeiro de São João Batista, s/n, Campus do Valonguinho Centro, 24020-150, Niterói, RJ, Brazil
* Authors to whom correspondence should be addressed.
Received: 14 May 2012; in revised form: 25 May 2012 / Accepted: 28 May 2012 / Published: 13 June 2012
Abstract: Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH•) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.
Keywords: antioxidant capacity; peroxyl radicals; coumarins; DPPH; cyclic voltammetry
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Vianna, D.R.; Bubols, G.; Meirelles, G.; Silva, B.V.; da Rocha, A.; Lanznaster, M.; Monserrat, J.M.; Garcia, S.C.; von Poser, G.; Eifler-Lima, V.L. Evaluation of the Antioxidant Capacity of Synthesized Coumarins. Int. J. Mol. Sci. 2012, 13, 7260-7270.
Vianna DR, Bubols G, Meirelles G, Silva BV, da Rocha A, Lanznaster M, Monserrat JM, Garcia SC, von Poser G, Eifler-Lima VL. Evaluation of the Antioxidant Capacity of Synthesized Coumarins. International Journal of Molecular Sciences. 2012; 13(6):7260-7270.
Vianna, Damiana R.; Bubols, Guilherme; Meirelles, Gabriela; Silva, Bárbara V.; da Rocha, Alessandra; Lanznaster, Maurício; Monserrat, José Maria; Garcia, Solange Cristina; von Poser, Gilsane; Eifler-Lima, Vera Lucia. 2012. "Evaluation of the Antioxidant Capacity of Synthesized Coumarins." Int. J. Mol. Sci. 13, no. 6: 7260-7270.