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Int. J. Mol. Sci. 2012, 13(6), 7260-7270; doi:10.3390/ijms13067260

Evaluation of the Antioxidant Capacity of Synthesized Coumarins

1,* , 1
1 Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil 2 Institute of Chemistry, Federal University of Rio de Janeiro, UFRJ, Bloco A, Cidade Universitária, 21941-909, Rio de Janeiro, RJ, Brazil 3 Post-Graduate Program in Physiological Sciences, Comparative Animal Physiology, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Av Itália km 8 s/n, 96201-900, Rio Grande, RS, Brazil 4 Institute of Chemistry, Universidade Federal Fluminense, UFF, Outeiro de São João Batista, s/n, Campus do Valonguinho Centro, 24020-150, Niterói, RJ, Brazil
* Authors to whom correspondence should be addressed.
Received: 14 May 2012 / Revised: 25 May 2012 / Accepted: 28 May 2012 / Published: 13 June 2012
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Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.
Keywords: antioxidant capacity; peroxyl radicals; coumarins; DPPH; cyclic voltammetry antioxidant capacity; peroxyl radicals; coumarins; DPPH; cyclic voltammetry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vianna, D.R.; Bubols, G.; Meirelles, G.; Silva, B.V.; da Rocha, A.; Lanznaster, M.; Monserrat, J.M.; Garcia, S.C.; von Poser, G.; Eifler-Lima, V.L. Evaluation of the Antioxidant Capacity of Synthesized Coumarins. Int. J. Mol. Sci. 2012, 13, 7260-7270.

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