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Int. J. Mol. Sci. 2012, 13(6), 7163-7173; doi:10.3390/ijms13067163

Antioxidant Activities of Extract and Fractions from Receptaculum Nelumbinis and Related Flavonol Glycosides

1
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2
Fujian Academy of Agricultural Sciences, Fuzhou 350013, China
3
Department of Chemistry and Life Science, Fujian Institute of Education, Fuzhou 350001, China
*
Author to whom correspondence should be addressed.
Received: 9 May 2012 / Revised: 29 May 2012 / Accepted: 5 June 2012 / Published: 11 June 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The antioxidant activities of ethanolic crude extract (ECE) and its four different solvent sub-fractions (namely, petroleum ether fraction (PEF), ethyl acetate fraction (EAF), n-butanol fraction (BF) and the aqueous fraction (AF) from the receptacles of Nelumbo nucifera Gaertn. (Receptaculum Nelumbinis) were investigated using two in vitro antioxidant assays. BF showed the highest total phenolic content (607.6 mg/g gallic acid equivalents), total flavonoid content (862.7 mg/g rutin equivalents) and total proanthocyanidin content (331.0 mg/g catechin equivalents), accompanied with the highest antioxidant activity compared to other fractions through 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. Five flavonol glycosides, namely hyperoside (1), isoquercitrin (2), quercetin-3-O-β-D-glucuronide (3), isorhamnetin-3-O-β-D-galactoside (4) and syringetin-3-O-β-D-glucoside (5) were isolated from the Receptaculum Nelumbinis. Compounds 25 were isolated for the first time from the Receptaculum Nelumbinis. The five isolated flavone glycosides, particularly compounds 13, demonstrated significant DPPH and ABTS radical scavenging activity, with IC50 values of 8.9 ± 0.2, 5.2 ± 0.2, 7.5 ± 0.1 for DPPH and 114.2 ± 1.7, 112.8 ± 0.8, 172.5 ± 0.7 µg/mL for ABTS, respectively. These results suggest that Receptaculum Nelumbinis has strong antioxidant potential and may be potentially used as a safe and inexpensive bioactive source of natural antioxidants. View Full-Text
Keywords: Nelumbo nucifera Gaertn.; receptacle; DPPH; ABTS Nelumbo nucifera Gaertn.; receptacle; DPPH; ABTS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wu, Y.-B.; Zheng, L.-J.; Wu, J.-G.; Chen, T.-Q.; Yi, J.; Wu, J.-Z. Antioxidant Activities of Extract and Fractions from Receptaculum Nelumbinis and Related Flavonol Glycosides. Int. J. Mol. Sci. 2012, 13, 7163-7173.

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