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Structural DNA Nanotechnology: From Design to Applications
Center for DNA Nanotechnology (CDNA), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark
Department of Chemistry, Marshall University, Huntington, WV 25755, USA
* Authors to whom correspondence should be addressed.
Received: 2 May 2012; in revised form: 29 May 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
Abstract: The exploitation of DNA for the production of nanoscale architectures presents a young yet paradigm breaking approach, which addresses many of the barriers to the self-assembly of small molecules into highly-ordered nanostructures via construct addressability. There are two major methods to construct DNA nanostructures, and in the current review we will discuss the principles and some examples of applications of both the tile-based and DNA origami methods. The tile-based approach is an older method that provides a good tool to construct small and simple structures, usually with multiply repeated domains. In contrast, the origami method, at this time, would appear to be more appropriate for the construction of bigger, more sophisticated and exactly defined structures.
Keywords: DNA nanotechnology; self-assembly; nanostructures; DNA origami
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Cite This Article
MDPI and ACS Style
Zadegan, R.M.; Norton, M.L. Structural DNA Nanotechnology: From Design to Applications. Int. J. Mol. Sci. 2012, 13, 7149-7162.
Zadegan RM, Norton ML. Structural DNA Nanotechnology: From Design to Applications. International Journal of Molecular Sciences. 2012; 13(6):7149-7162.
Zadegan, Reza M.; Norton, Michael L. 2012. "Structural DNA Nanotechnology: From Design to Applications." Int. J. Mol. Sci. 13, no. 6: 7149-7162.