Inflammation Amplification by Versican: The First Mediator
AbstractThe effects of inflammation may not always benefit the individual. Its amplifying nature represents a highly regulated biological program, and the inflammatory microenvironment is its essential component. Growing evidence suggests that the ECM (extracellular matrix) is important for the early steps of inflammation. Versican, a ubiquitous component of the ECM, contributes to the formation of the inflammatory response and is highly regulated by cytokines. Certain cytokines exert their initial effects on versican to alter the homeostasis of the inflammatory milieu, and inappropriate production of versican may promote the next inflammatory response. Therefore, versican could be the first step in the amplification of the inflammatory response, and ongoing research of this molecule may help to explain the pathogenesis of inflammation.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Zhang, Z.; Miao, L.; Wang, L. Inflammation Amplification by Versican: The First Mediator. Int. J. Mol. Sci. 2012, 13, 6873-6882.
Zhang Z, Miao L, Wang L. Inflammation Amplification by Versican: The First Mediator. International Journal of Molecular Sciences. 2012; 13(6):6873-6882.Chicago/Turabian Style
Zhang, Zhenwei; Miao, Lei; Wang, Lianghua. 2012. "Inflammation Amplification by Versican: The First Mediator." Int. J. Mol. Sci. 13, no. 6: 6873-6882.