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Int. J. Mol. Sci. 2012, 13(6), 6873-6882; doi:10.3390/ijms13066873

Inflammation Amplification by Versican: The First Mediator

1 Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China 2 Department of Pharmacology, Zhejiang Chinese Medical University, Hangzhou 310053, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 20 April 2012 / Revised: 3 May 2012 / Accepted: 29 May 2012 / Published: 6 June 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The effects of inflammation may not always benefit the individual. Its amplifying nature represents a highly regulated biological program, and the inflammatory microenvironment is its essential component. Growing evidence suggests that the ECM (extracellular matrix) is important for the early steps of inflammation. Versican, a ubiquitous component of the ECM, contributes to the formation of the inflammatory response and is highly regulated by cytokines. Certain cytokines exert their initial effects on versican to alter the homeostasis of the inflammatory milieu, and inappropriate production of versican may promote the next inflammatory response. Therefore, versican could be the first step in the amplification of the inflammatory response, and ongoing research of this molecule may help to explain the pathogenesis of inflammation.
Keywords: versican; cytokines; extracellular matrix homeostasis; inflammation amplification versican; cytokines; extracellular matrix homeostasis; inflammation amplification
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, Z.; Miao, L.; Wang, L. Inflammation Amplification by Versican: The First Mediator. Int. J. Mol. Sci. 2012, 13, 6873-6882.

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