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Int. J. Mol. Sci. 2012, 13(6), 6747-6756; doi:10.3390/ijms13066747

Opuntia humifusa Supplementation Increased Bone Density by Regulating Parathyroid Hormone and Osteocalcin in Male Growing Rats

1
Laboratory of Sports Nutrition, Sunmoon University, Asan, 336-708, Republic of Korea
2
Department of Food Science, Sunmoon University, Asan, 336-708, Republic of Korea
3
Department of Healthcare, Nippon Sport Science University, Yokohama, 227-0033, Japan
*
Author to whom correspondence should be addressed.
Received: 2 May 2012 / Revised: 24 May 2012 / Accepted: 28 May 2012 / Published: 4 June 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

We investigated the effect of Opuntia humifusa (O. humifusa) supplementation on bone density and related hormone secretion in growing male rats. Sixteen six-week-old male Sprague-Dawley rats were randomly divided into two groups; control diet group (CG, n = 8), and experimental diet group (EG, n = 8). The rats in the CG were given a control diet and those in the EG were given 5% O. humifusa added to the control diet for eight weeks. The serum OC level of the EG was significantly higher than that of the CG, and the serum parathyroid hormone (PTH) level of EG was significantly lower than that of the CG. In addition, the femoral and tibial BMD of the EG were significantly higher values than those of the CG, and the tibial BMC of the EG was significantly higher than that of the CG. These results suggest that O. humifusa supplementation has a positive effect on bone density by suppressing PTH and increasing the OC level in growing male rats.
Keywords: O. humifusa; bone density; parathyroid hormone; osteocalcin; rat O. humifusa; bone density; parathyroid hormone; osteocalcin; rat
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kang, J.; Park, J.; Choi, S.H.; Igawa, S.; Song, Y. Opuntia humifusa Supplementation Increased Bone Density by Regulating Parathyroid Hormone and Osteocalcin in Male Growing Rats. Int. J. Mol. Sci. 2012, 13, 6747-6756.

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