Int. J. Mol. Sci. 2012, 13(6), 6730-6746; doi:10.3390/ijms13066730

Rapid Synthesis and Antiviral Activity of (Quinazolin-4-Ylamino)Methyl-Phosphonates Through Microwave Irradiation

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Received: 31 March 2012; in revised form: 8 May 2012 / Accepted: 8 May 2012 / Published: 1 June 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This study describes the simple synthesis of new (quinazolin-4-ylamino) methylphosphonates via microwave irradiation. Substituted-2-aminobenzonitrile reacted with 1,1-dimethoxy-N,N-dimethylmethanamine at a reflux condition to obtain N'-(substituted-2-cyanophenyl)-N,N-dimethylformamidine (1). The subsequent reaction of this intermediate product with α-aminophosphonate (2) in a solution containing glacial acetic acid in 2-propanol through microwave irradiation resulted in the formation of (quinazolin-4-ylamino)methyl-phosphonate derivatives 3a to 3x, which were unequivocally characterized by the spectral data and elemental analysis. The influence of the reaction conditions on the yield of 3a was investigated to optimize the synthetic conditions. The relative optimal conditions for the synthesis of 3a include a 1:1 molar ratio of N’-(2-cyanophenyl)-N,N-dimethylformamidine to diethyl amino(phenyl)methylphosphonate and a 4:1 volume ratio of isopropanol to HOAc in the solvent mixture, at a reaction temperature of 150 °C, with a microwave power of 100 W and a corresponding pressure of 150 psi for 20 min in the microwave synthesizer. The yield of 3a was approximately 79%, whereas those of 3b to 3x were approximately 77% to 86%. Some of the synthesized compounds displayed weak to good anti-Tobacco mosaic virus (TMV) activity.
Keywords: quinazoline derivatives; α-aminophosphonate moiety; synthesis; microwave irradiation
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MDPI and ACS Style

Luo, H.; Hu, D.; Wu, J.; He, M.; Jin, L.; Yang, S.; Song, B. Rapid Synthesis and Antiviral Activity of (Quinazolin-4-Ylamino)Methyl-Phosphonates Through Microwave Irradiation. Int. J. Mol. Sci. 2012, 13, 6730-6746.

AMA Style

Luo H, Hu D, Wu J, He M, Jin L, Yang S, Song B. Rapid Synthesis and Antiviral Activity of (Quinazolin-4-Ylamino)Methyl-Phosphonates Through Microwave Irradiation. International Journal of Molecular Sciences. 2012; 13(6):6730-6746.

Chicago/Turabian Style

Luo, Hui; Hu, Deyu; Wu, Jian; He, Ming; Jin, Linhong; Yang, Song; Song, Baoan. 2012. "Rapid Synthesis and Antiviral Activity of (Quinazolin-4-Ylamino)Methyl-Phosphonates Through Microwave Irradiation." Int. J. Mol. Sci. 13, no. 6: 6730-6746.

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