Int. J. Mol. Sci. 2012, 13(5), 6440-6451; doi:10.3390/ijms13056440

Phytochemical and Biological Studies of Agave attenuata

1 Department of Chemistry, Government College University, Faisalabad 38000, Pakistan 2 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan 3 Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy
* Author to whom correspondence should be addressed.
Received: 27 March 2012; in revised form: 14 April 2012 / Accepted: 4 May 2012 / Published: 24 May 2012
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Abstract: The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g) and total flavonoid contents (43.35–304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.
Keywords: Agave attenuata; GC-MS; peroxidation; volatile fraction; flavonoids; phenolics

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MDPI and ACS Style

Rizwan, K.; Zubair, M.; Rasool, N.; Riaz, M.; Zia-Ul-Haq, M.; de Feo, V. Phytochemical and Biological Studies of Agave attenuata. Int. J. Mol. Sci. 2012, 13, 6440-6451.

AMA Style

Rizwan K, Zubair M, Rasool N, Riaz M, Zia-Ul-Haq M, de Feo V. Phytochemical and Biological Studies of Agave attenuata. International Journal of Molecular Sciences. 2012; 13(5):6440-6451.

Chicago/Turabian Style

Rizwan, Komal; Zubair, Muhammad; Rasool, Nasir; Riaz, Muhammad; Zia-Ul-Haq, Muhammad; de Feo, Vincenzo. 2012. "Phytochemical and Biological Studies of Agave attenuata." Int. J. Mol. Sci. 13, no. 5: 6440-6451.

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