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• Rizwan, K
• Zubair, M
• Rasool, N
• Riaz, M
• Zia-Ul-Haq, M
• de Feo, V
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• Rizwan, K
• Zubair, M
• Rasool, N
• Riaz, M
• Zia-Ul-Haq, M
• de Feo, V
• [+] on PubMed
• Rizwan, K
• Zubair, M
• Rasool, N
• Riaz, M
• Zia-Ul-Haq, M
• de Feo, V

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Int. J. Mol. Sci. 2012, 13(5), 6440-6451; doi:10.3390/ijms13056440

Article

Phytochemical and Biological Studies of Agave attenuata

Komal Rizwan ¹ , Muhammad Zubair ¹ , Nasir Rasool ¹ , Muhammad Riaz ¹ , Muhammad Zia-Ul-Haq ²  and Vincenzo de Feo ^3,*

¹ Department of Chemistry, Government College University, Faisalabad 38000, Pakistan ² Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan ³ Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy

* Author to whom correspondence should be addressed.

Received: 27 March 2012; in revised form: 14 April 2012 / Accepted: 4 May 2012 / Published: 24 May 2012

Download PDF Full-Text [173 KB, uploaded 24 May 2012 09:40 CEST]

Abstract: The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g) and total flavonoid contents (43.35–304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.

Keywords: Agave attenuata; GC-MS; peroxidation; volatile fraction; flavonoids; phenolics

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