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Int. J. Mol. Sci. 2012, 13(5), 6440-6451; doi:10.3390/ijms13056440
Article

Phytochemical and Biological Studies of Agave attenuata

1
,
1
,
1
,
1
,
2
 and
3,*
1 Department of Chemistry, Government College University, Faisalabad 38000, Pakistan 2 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan 3 Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy
* Author to whom correspondence should be addressed.
Received: 27 March 2012 / Revised: 14 April 2012 / Accepted: 4 May 2012 / Published: 24 May 2012
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Abstract

The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g) and total flavonoid contents (43.35–304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.
Keywords: Agave attenuata; GC-MS; peroxidation; volatile fraction; flavonoids; phenolics Agave attenuata; GC-MS; peroxidation; volatile fraction; flavonoids; phenolics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Rizwan, K.; Zubair, M.; Rasool, N.; Riaz, M.; Zia-Ul-Haq, M.; de Feo, V. Phytochemical and Biological Studies of Agave attenuata. Int. J. Mol. Sci. 2012, 13, 6440-6451.

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