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Phytochemical and Biological Studies of Agave attenuata
Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy
* Author to whom correspondence should be addressed.
Received: 27 March 2012; in revised form: 14 April 2012 / Accepted: 4 May 2012 / Published: 24 May 2012
Abstract: The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g) and total flavonoid contents (43.35–304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.
Keywords: Agave attenuata; GC-MS; peroxidation; volatile fraction; flavonoids; phenolics
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Rizwan, K.; Zubair, M.; Rasool, N.; Riaz, M.; Zia-Ul-Haq, M.; de Feo, V. Phytochemical and Biological Studies of Agave attenuata. Int. J. Mol. Sci. 2012, 13, 6440-6451.
Rizwan K, Zubair M, Rasool N, Riaz M, Zia-Ul-Haq M, de Feo V. Phytochemical and Biological Studies of Agave attenuata. International Journal of Molecular Sciences. 2012; 13(5):6440-6451.
Rizwan, Komal; Zubair, Muhammad; Rasool, Nasir; Riaz, Muhammad; Zia-Ul-Haq, Muhammad; de Feo, Vincenzo. 2012. "Phytochemical and Biological Studies of Agave attenuata." Int. J. Mol. Sci. 13, no. 5: 6440-6451.