Next Article in Journal
Introgression Between Cultivars and Wild Populations of Momordica charantia L. (Cucurbitaceae) in Taiwan
Previous Article in Journal
Correction: Nanostructured Biomaterials for Tissue Engineered Bone Tissue Reconstruction. Int. J. Mol. Sci. 2012, 13, 737-757
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2012, 13(5), 6454-6468; doi:10.3390/ijms13056454

A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles

1,2,†,* , 1,†
,
1
,
2
and
2,*
1
Department of Clinical Pharmacology, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China
2
College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 February 2012 / Revised: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012
(This article belongs to the Section Material Sciences and Nanotechnology)
View Full-Text   |   Download PDF [633 KB, uploaded 19 June 2014]   |  

Abstract

In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.
Keywords: supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hu, D.; Liu, L.; Chen, W.; Li, S.; Zhao, Y. A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles. Int. J. Mol. Sci. 2012, 13, 6454-6468.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top