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A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles
Department of Clinical Pharmacology, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China
College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 13 February 2012; in revised form: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012
Abstract: In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.
Keywords: supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific
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Hu, D.; Liu, L.; Chen, W.; Li, S.; Zhao, Y. A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles. Int. J. Mol. Sci. 2012, 13, 6454-6468.
Hu D, Liu L, Chen W, Li S, Zhao Y. A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles. International Journal of Molecular Sciences. 2012; 13(5):6454-6468.
Hu, Daode; Liu, Liang; Chen, Wenjuan; Li, Sining; Zhao, Yaping. 2012. "A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles." Int. J. Mol. Sci. 13, no. 5: 6454-6468.