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Correction: Nanostructured Biomaterials for Tissue Engineered Bone Tissue Reconstruction. Int. J. Mol. Sci. 2012, 13, 737-757
Int. J. Mol. Sci. 2012, 13(5), 6454-6468; doi:10.3390/ijms13056454
Article

A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles

1,2,†,* , 1,†
,
1
,
2
 and
2,*
1 Department of Clinical Pharmacology, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China 2 College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 13 February 2012 / Revised: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012
(This article belongs to the Section Material Sciences and Nanotechnology)
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Abstract

In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.
Keywords: supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Hu, D.; Liu, L.; Chen, W.; Li, S.; Zhao, Y. A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles. Int. J. Mol. Sci. 2012, 13, 6454-6468.

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