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Correction: Nanostructured Biomaterials for Tissue Engineered Bone Tissue Reconstruction. Int. J. Mol. Sci. 2012, 13, 737-757
Int. J. Mol. Sci. 2012, 13(5), 6454-6468; doi:10.3390/ijms13056454
Article

A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles

1,2,†,* , 1,†
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1
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2
 and
2,*
Received: 13 February 2012 / Revised: 22 April 2012 / Accepted: 22 May 2012 / Published: 24 May 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.
Keywords: supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific supercritical antisolvent; solution enhanced dispersion by supercritical fluids; Eudragit S100; 5-ASA; nanoparticles; colon-specific
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, D.; Liu, L.; Chen, W.; Li, S.; Zhao, Y. A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles. Int. J. Mol. Sci. 2012, 13, 6454-6468.

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