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CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer
Department of General Surgery, Tongji Hospital of Tongji University, Shanghai 200065, China
Central Laboratory, Tongji Hospital of Tongji University, Shanghai 200065, China
School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 18 April 2012; in revised form: 15 May 2012 / Accepted: 15 May 2012 / Published: 23 May 2012
Abstract: CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers.
Keywords: CD146; gastric cancer; epithelial-mesenchymal transition; prognosis; immunohistochemistry
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MDPI and ACS Style
Liu, W.-F.; Ji, S.-R.; Sun, J.-J.; Zhang, Y.; Liu, Z.-Y.; Liang, A.-B.; Zeng, H.-Z. CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer. Int. J. Mol. Sci. 2012, 13, 6399-6406.
Liu W-F, Ji S-R, Sun J-J, Zhang Y, Liu Z-Y, Liang A-B, Zeng H-Z. CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer. International Journal of Molecular Sciences. 2012; 13(5):6399-6406.
Liu, Wen-Fang; Ji, Shu-Rong; Sun, Jian-Jun; Zhang, Yi; Liu, Zhong-Yan; Liang, Ai-Bin; Zeng, Hua-Zong. 2012. "CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer." Int. J. Mol. Sci. 13, no. 5: 6399-6406.