Abstract: CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers.
Keywords: CD146; gastric cancer; epithelial-mesenchymal transition; prognosis; immunohistochemistry
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Liu, W.-F.; Ji, S.-R.; Sun, J.-J.; Zhang, Y.; Liu, Z.-Y.; Liang, A.-B.; Zeng, H.-Z. CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer. Int. J. Mol. Sci. 2012, 13, 6399-6406.
Liu W-F, Ji S-R, Sun J-J, Zhang Y, Liu Z-Y, Liang A-B, Zeng H-Z. CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer. International Journal of Molecular Sciences. 2012; 13(5):6399-6406.
Liu, Wen-Fang; Ji, Shu-Rong; Sun, Jian-Jun; Zhang, Yi; Liu, Zhong-Yan; Liang, Ai-Bin; Zeng, Hua-Zong. 2012. "CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer." Int. J. Mol. Sci. 13, no. 5: 6399-6406.