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Int. J. Mol. Sci. 2012, 13(5), 6236-6245; doi:10.3390/ijms13056236
Article

Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway

1
, 1
, 2
, 2
, 3
, 2
, 4
, 5
, 6,7
, 8
 and 2,*
1 Department of Life Science and Institute of Zoology, National Taiwan University, Taipei 106, Taiwan 2 Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Fragrance and Cosmetics Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan 4 Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung 807, Taiwan 5 Chest Surgery, Chi-Mei Foundation Medical Center, Yung Kang City, Tainan 901, Taiwan 6 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan 7 Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 8 Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien Hai Road, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 4 April 2012 / Revised: 7 May 2012 / Accepted: 14 May 2012 / Published: 21 May 2012
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

Caffeic acid (CA), a natural phenolic compound, is abundant in medicinal plants. CA possesses multiple biological effects such as anti-bacterial and anti-cancer growth. CA was also reported to induce fore stomach and kidney tumors in a mouse model. Here we used two human lung cancer cell lines, A549 and H1299, to clarify the role of CA in cancer cell proliferation. The growth assay showed that CA moderately promoted the proliferation of the lung cancer cells. Furthermore, pre-treatment of CA rescues the proliferation inhibition induced by a sub-IC50 dose of paclitaxel (PTX), an anticancer drug. Western blot showed that CA up-regulated the pro-survival proteins survivin and Bcl-2, the down-stream targets of NF-κB. This is consistent with the observation that CA induced nuclear translocation of NF-κB p65. Our study suggested that the pro-survival effect of CA on PTX-treated lung cancer cells is mediated through a NF-κB signaling pathway. This may provide mechanistic insights into the chemoresistance of cancer calls.
Keywords: caffeic acid; non-small cell lung cancer; paclitaxel; survivin; Bcl-2; NF-κB caffeic acid; non-small cell lung cancer; paclitaxel; survivin; Bcl-2; NF-κB
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, C.-L.; Chen, R.-F.; Chen, J.-F.; Chu, Y.-C.; Wang, H.-M.; Chou, H.-L.; Chang, W.-C.; Fong, Y.; Chang, W.-T.; Wu, C.-Y.; Chiu, C.-C. Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway. Int. J. Mol. Sci. 2012, 13, 6236-6245.

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