Next Article in Journal
Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells
Previous Article in Journal
Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2012, 13(5), 5740-5750; https://doi.org/10.3390/ijms13055740

Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats

1
Department of Biomaterial Control (BK21 Program), Dong-Eui University Graduate School, Busan 614-714, Korea
2
Department of Pathology, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea
3
Department of Biotechnology and Bioengineering, Dong-Eui University, Busan 614-714, Korea
4
Blue-Bio Industry RIC, Dong-Eui University, Busan 614-714, Korea
5
Anti-Aging Research Center, Dong-Eui University, Busan 614-714, Korea
6
Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea
*
Author to whom correspondence should be addressed.
Received: 11 April 2012 / Revised: 1 May 2012 / Accepted: 7 May 2012 / Published: 11 May 2012
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [255 KB, uploaded 19 June 2014]

Abstract

In the present study, we examined the gastroprotective effect of selenium against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 80% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of selenium on ethanol-induced gastric damage, various doses of selenium were given as pretreatment for three days, and then gastric damage was induced by 80% ethanol treatment. Selenium showed a protective effect against ethanol-induced gastric mucosal lesions in a dose dependent manner. Specifically, 100 μg/kg selenium showed the highest level of gastroprotection. In addition, selenium markedly attenuated ethanol-induced lipid peroxidation in gastric mucosa and increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. Histological data showed that 100 μg/kg selenium distinctly reduced the depth and severity of the ethanol induced gastric lesion. These results clearly demonstrate that selenium inhibits the formation of ethanol-induced gastric mucosal lesions through prevention of lipid peroxidation and activation of enzymatic radical scavenging. View Full-Text
Keywords: selenium; ethanol; gastric mucosal lesions; radical scavenging enzymes selenium; ethanol; gastric mucosal lesions; radical scavenging enzymes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kim, J.-H.; Park, S.-H.; Nam, S.-W.; Choi, Y.-H. Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats. Int. J. Mol. Sci. 2012, 13, 5740-5750.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top