Int. J. Mol. Sci. 2012, 13(5), 5729-5739; doi:10.3390/ijms13055729
Article

Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells

1,†email, 1,†email, 2email, 3email and 1,* email
Received: 28 February 2012; in revised form: 10 April 2012 / Accepted: 7 May 2012 / Published: 11 May 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cardiovascular disease (CVD) is one of the main causes of mortality worldwide, and dyslipidemia is a major risk factor for CVD. Ginseng has been widely used in the clinic to treat CVD. Ginsenoside Rg3, one of the major active components of ginseng, has been reported to exhibit antiobesity, antidiabetic, and cardioprotective effects. However, the effect of ginsenoside Rg3 on hepatic lipid metabolism remains unclear. Therefore, we investigated whether ginsenoside Rg3 would regulate hepatic lipid metabolism with AMP-activated protein kinase (AMPK) activation in HepG2 cells. Ginsenoside Rg3 significantly reduced hepatic cholesterol and triglyceride levels. Furthermore, ginsenoside Rg3 inhibited expression of sterol regulatory element binding protein-2 (SREBP-2) and 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR). Ginsenoside Rg3 increased activity of AMPK, a major regulator of energy metabolism. These results suggest that ginsenoside Rg3 reduces hepatic lipid accumulation with inhibition of SREBP-2 and HMGCR expression and stimulation of AMPK activity in HepG2 cells. Therefore, ginsenoside Rg3 may be beneficial as a food ingredient to lower the risk of CVD by regulating dyslipidemia.
Keywords: Cardiovascular disease (CVD); ginsenoside Rg3; cholesterol; triglyceride; SREBP-2; HMGCR; AMPK
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MDPI and ACS Style

Lee, S.; Lee, M.-S.; Kim, C.-T.; Kim, I.-H.; Kim, Y. Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells. Int. J. Mol. Sci. 2012, 13, 5729-5739.

AMA Style

Lee S, Lee M-S, Kim C-T, Kim I-H, Kim Y. Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells. International Journal of Molecular Sciences. 2012; 13(5):5729-5739.

Chicago/Turabian Style

Lee, Seohyun; Lee, Mak-Soon; Kim, Chong-Tai; Kim, In-Hwan; Kim, Yangha. 2012. "Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells." Int. J. Mol. Sci. 13, no. 5: 5729-5739.


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