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Int. J. Mol. Sci. 2012, 13(5), 5740-5750; doi:10.3390/ijms13055740
Article

Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats

1
, 2
, 1,3,4
 and 4,5,6,*
1 Department of Biomaterial Control (BK21 Program), Dong-Eui University Graduate School, Busan 614-714, Korea 2 Department of Pathology, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea 3 Department of Biotechnology and Bioengineering, Dong-Eui University, Busan 614-714, Korea 4 Blue-Bio Industry RIC, Dong-Eui University, Busan 614-714, Korea 5 Anti-Aging Research Center, Dong-Eui University, Busan 614-714, Korea 6 Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea
* Author to whom correspondence should be addressed.
Received: 11 April 2012 / Revised: 1 May 2012 / Accepted: 7 May 2012 / Published: 11 May 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

In the present study, we examined the gastroprotective effect of selenium against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 80% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of selenium on ethanol-induced gastric damage, various doses of selenium were given as pretreatment for three days, and then gastric damage was induced by 80% ethanol treatment. Selenium showed a protective effect against ethanol-induced gastric mucosal lesions in a dose dependent manner. Specifically, 100 μg/kg selenium showed the highest level of gastroprotection. In addition, selenium markedly attenuated ethanol-induced lipid peroxidation in gastric mucosa and increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. Histological data showed that 100 μg/kg selenium distinctly reduced the depth and severity of the ethanol induced gastric lesion. These results clearly demonstrate that selenium inhibits the formation of ethanol-induced gastric mucosal lesions through prevention of lipid peroxidation and activation of enzymatic radical scavenging.
Keywords: selenium; ethanol; gastric mucosal lesions; radical scavenging enzymes selenium; ethanol; gastric mucosal lesions; radical scavenging enzymes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kim, J.-H.; Park, S.-H.; Nam, S.-W.; Choi, Y.-H. Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats. Int. J. Mol. Sci. 2012, 13, 5740-5750.

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