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Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats
Department of Biomaterial Control (BK21 Program), Dong-Eui University Graduate School, Busan 614-714, Korea
Department of Pathology, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea
Department of Biotechnology and Bioengineering, Dong-Eui University, Busan 614-714, Korea
Blue-Bio Industry RIC, Dong-Eui University, Busan 614-714, Korea
Anti-Aging Research Center, Dong-Eui University, Busan 614-714, Korea
Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea
* Author to whom correspondence should be addressed.
Received: 11 April 2012; in revised form: 1 May 2012 / Accepted: 7 May 2012 / Published: 11 May 2012
Abstract: In the present study, we examined the gastroprotective effect of selenium against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 80% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of selenium on ethanol-induced gastric damage, various doses of selenium were given as pretreatment for three days, and then gastric damage was induced by 80% ethanol treatment. Selenium showed a protective effect against ethanol-induced gastric mucosal lesions in a dose dependent manner. Specifically, 100 μg/kg selenium showed the highest level of gastroprotection. In addition, selenium markedly attenuated ethanol-induced lipid peroxidation in gastric mucosa and increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. Histological data showed that 100 μg/kg selenium distinctly reduced the depth and severity of the ethanol induced gastric lesion. These results clearly demonstrate that selenium inhibits the formation of ethanol-induced gastric mucosal lesions through prevention of lipid peroxidation and activation of enzymatic radical scavenging.
Keywords: selenium; ethanol; gastric mucosal lesions; radical scavenging enzymes
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Kim, J.-H.; Park, S.-H.; Nam, S.-W.; Choi, Y.-H. Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats. Int. J. Mol. Sci. 2012, 13, 5740-5750.
Kim J-H, Park S-H, Nam S-W, Choi Y-H. Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats. International Journal of Molecular Sciences. 2012; 13(5):5740-5750.
Kim, Jeong-Hwan; Park, Shin-Hyung; Nam, Soo-Wan; Choi, Yung-Hyun. 2012. "Gastroprotective Effect of Selenium on Ethanol-Induced Gastric Damage in Rats." Int. J. Mol. Sci. 13, no. 5: 5740-5750.