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Nonselective Blocking of the Sympathetic Nervous System Decreases Detrusor Overactivity in Spontaneously Hypertensive Rats
Departments of Urology, Gachon University Gil Hospital, Incheon 405-760, Korea
Departments of Urology, Inha University College of Medicine, Incheon 402-751, Korea
Department of Preventive and Social Medicine, Inha University College of Medicine, Incheon 402-751, Korea
Department of Pharmacology, Inha University College of Medicine, Incheon 402-751, Korea
Department of Physiology and Biophysics, Inha university College of Medicine, Incheon 402-751, Korea
* Authors to whom correspondence should be addressed.
Received: 5 March 2012; in revised form: 20 April 2012 / Accepted: 20 April 2012 / Published: 23 April 2012
Abstract: The involuntary dual control systems of the autonomic nervous system (ANS) in the bladder of awake spontaneously hypertensive rats (SHRs) were investigated through simultaneous registrations of intravesical and intraabdominal pressures to observe detrusor overactivity (DO) objectively as a core symptom of an overactive bladder. SHRs (n = 6) showed the features of overactive bladder syndrome during urodynamic study, especially DO during the filling phase. After injection of the nonselective sympathetic blocking agent labetalol, DO disappeared in 3 of 6 SHRs (50%). DO frequency decreased from 0.98 ± 0.22 min−1 to 0.28 ± 0.19 min−1 (p < 0.01), and DO pressure decreased from 3.82 ± 0.57 cm H2O to 1.90 ± 0.86 cm H2O (p < 0.05). This suggests that the DO originating from the overactive parasympathetic nervous system is attenuated by the nonselective blocking of the sympathetic nervous system. The detailed mechanism behind this result is still not known, but parasympathetic overactivity seems to require overactive sympathetic nervous system activity in a kind of balance between these two systems. These findings are consistent with recent clinical findings suggesting that patients with idiopathic overactive bladder may have ANS dysfunction, particularly a sympathetic dysfunction. The search for newer and better drugs than the current anticholinergic drugs as the mainstay for overactive bladder will be fueled by our research on these sympathetic mechanisms. Further studies of this principle are required.
Keywords: autonomic nervous system; detrusor overactivity; labetalol
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Kim, K.-H.; Jin, L.-H.; Choo, G.-Y.; Lee, H.-J.; Choi, B.-H.; Kwak, J.; Yoon, S.-M.; Park, C.-S.; Lee, T. Nonselective Blocking of the Sympathetic Nervous System Decreases Detrusor Overactivity in Spontaneously Hypertensive Rats. Int. J. Mol. Sci. 2012, 13, 5048-5059.
Kim K-H, Jin L-H, Choo G-Y, Lee H-J, Choi B-H, Kwak J, Yoon S-M, Park C-S, Lee T. Nonselective Blocking of the Sympathetic Nervous System Decreases Detrusor Overactivity in Spontaneously Hypertensive Rats. International Journal of Molecular Sciences. 2012; 13(4):5048-5059.
Kim, Khae-Hawn; Jin, Long-Hu; Choo, Gwoan-Youb; Lee, Hun-Jae; Choi, Bo-Hwa; Kwak, Jiyeon; Yoon, Sang-Min; Park, Chang-Shin; Lee, Tack. 2012. "Nonselective Blocking of the Sympathetic Nervous System Decreases Detrusor Overactivity in Spontaneously Hypertensive Rats." Int. J. Mol. Sci. 13, no. 4: 5048-5059.