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Int. J. Mol. Sci. 2012, 13(4), 5035-5047; doi:10.3390/ijms13045035
Article

A Novel and Expedient Approach to New Thiazoles, Thiazolo[3,2-a]pyridines, Dihydrothiophenes, and Hydrazones Incorporating Thieno[2,3-b]thiophene Moiety

1,* , 1,* , 1
,
1
 and
2
1 Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2 Department of Chemistry, Faculty of Applied Science, Thamar University, P.O. Box 87246, Yemen
* Authors to whom correspondence should be addressed.
Received: 1 March 2012 / Revised: 31 March 2012 / Accepted: 12 April 2012 / Published: 23 April 2012
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Abstract

This paper reports details about the synthesis of a series of novel functionalized symmetrical bis-heterocyclic compounds containing a thieno[2,3-b]thiophene motif. Bis-thiazole derivatives 2, 3a-c and thiazolo[3,2-a]pyridine derivatives 4a-c are achieved. The hitherto unknown dihydrothiophene derivatives 6a-d via bis-pyridimium salt 5 are obtained. Additionally, the novel hydrazonothieno[2,3-b]thiophene derivatives 10a-c are obtained via bis-tosylacetylthieno[2,3-b]thiophene derivative 9. All compounds are characterized by 1H-, 13C-NMR, GCMS, IR, and UV-vis spectrometry. These compounds represent a new class of sulfur and nitrogen containing heterocycles that should also be of interest as new materials.
Keywords: thiazolo[3,2-a]pyridine; dihydrothiphene; thieno[2,3-b]thiophene; symmetrical bis-heterocycle thiazolo[3,2-a]pyridine; dihydrothiphene; thieno[2,3-b]thiophene; symmetrical bis-heterocycle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mabkhot, Y.N.; Barakat, A.; Al-Majid, A.M.; Alamary, A.S.; Al-Nahary, T.T. A Novel and Expedient Approach to New Thiazoles, Thiazolo[3,2-a]pyridines, Dihydrothiophenes, and Hydrazones Incorporating Thieno[2,3-b]thiophene Moiety. Int. J. Mol. Sci. 2012, 13, 5035-5047.

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