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Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
Department of Pulmonary Medicine, Detection Center of Tumor Biomarker, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China
Department of Pulmonary Medicine, First People’s Hospital of Xi’an, 710032 Xi’an, China
Department of Radiology, Medical Imaging Center, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 6 February 2012; in revised form: 5 March 2012 / Accepted: 15 March 2012 / Published: 22 March 2012
Abstract: Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a potential adjuvant anti-cancer agent to chemotherapy. Previous investigations focus on the mechanisms of action for curcumin, which is shown to manipulate transcription factors and induce apoptosis in various kinds of human cancer. Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. The present review predominantly discusses significance of EGFR, miRNA, autophagy and cancer stem cell in lung cancer therapy. Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy. Additionally, curcumin is well tolerated in humans. Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer.
Keywords: lung cancer; curcumin; EGFR; miRNA; autophagy; cancer stem cell
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MDPI and ACS Style
Ye, M.-X.; Li, Y.; Yin, H.; Zhang, J. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer. Int. J. Mol. Sci. 2012, 13, 3959-3978.
Ye M-X, Li Y, Yin H, Zhang J. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer. International Journal of Molecular Sciences. 2012; 13(3):3959-3978.
Ye, Ming-Xiang; Li, Yan; Yin, Hong; Zhang, Jian. 2012. "Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer." Int. J. Mol. Sci. 13, no. 3: 3959-3978.