Next Article in Journal
Therapeutic Effect of Arsenicum album on Leukocytes
Previous Article in Journal
Cooperative Modulation of Mineral Growth by Prismatic-Associated Asprich Sequences and Mg(II)
Int. J. Mol. Sci. 2012, 13(3), 3959-3978; doi:10.3390/ijms13033959

Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer

3,*  and 1,*
Received: 6 February 2012 / Revised: 5 March 2012 / Accepted: 15 March 2012 / Published: 22 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [385 KB, uploaded 19 June 2014]   |   Browse Figures


Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a potential adjuvant anti-cancer agent to chemotherapy. Previous investigations focus on the mechanisms of action for curcumin, which is shown to manipulate transcription factors and induce apoptosis in various kinds of human cancer. Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. The present review predominantly discusses significance of EGFR, miRNA, autophagy and cancer stem cell in lung cancer therapy. Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy. Additionally, curcumin is well tolerated in humans. Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer.
Keywords: lung cancer; curcumin; EGFR; miRNA; autophagy; cancer stem cell lung cancer; curcumin; EGFR; miRNA; autophagy; cancer stem cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Ye, M.-X.; Li, Y.; Yin, H.; Zhang, J. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer. Int. J. Mol. Sci. 2012, 13, 3959-3978.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert