Int. J. Mol. Sci. 2012, 13(3), 3847-3886; doi:10.3390/ijms13033847
Review

Functionalized Nanostructures with Application in Regenerative Medicine

Macarena Perán 1 email, María A. García 2 email, Elena López-Ruiz 1 email, Milán Bustamante 3 email, Gema Jiménez 4 email, Roberto Madeddu 5 email and Juan A. Marchal 4,6,* email
1 Department of Health Sciences, University of Jaén, Jaén E-23071, Spain 2 Research Unit, Hospital Universitario Virgen de las Nieves, Granada E-18014, Spain 3 Biosciences Institute, University College Cork, Cork, Ireland 4 Biopathology and Regenerative Medicine Institute (IBIMER), Biomedical Research Centre, University of Granada, Granada E-18100, Spain 5 Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy 6 Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada E-18012, Spain
* Author to whom correspondence should be addressed.
Received: 29 January 2012; in revised form: 3 March 2012 / Accepted: 6 March 2012 / Published: 22 March 2012
(This article belongs to the Special Issue From Molecules to Nanomaterials)
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Abstract: In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.
Keywords: regenerative medicine; nanomaterials; scaffolds; cell therapy; stem cells; bone; cartilage; cell encapsulation; cell tracking; gene and drug delivery

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MDPI and ACS Style

Perán, M.; García, M.A.; López-Ruiz, E.; Bustamante, M.; Jiménez, G.; Madeddu, R.; Marchal, J.A. Functionalized Nanostructures with Application in Regenerative Medicine. Int. J. Mol. Sci. 2012, 13, 3847-3886.

AMA Style

Perán M, García MA, López-Ruiz E, Bustamante M, Jiménez G, Madeddu R, Marchal JA. Functionalized Nanostructures with Application in Regenerative Medicine. International Journal of Molecular Sciences. 2012; 13(3):3847-3886.

Chicago/Turabian Style

Perán, Macarena; García, María A.; López-Ruiz, Elena; Bustamante, Milán; Jiménez, Gema; Madeddu, Roberto; Marchal, Juan A. 2012. "Functionalized Nanostructures with Application in Regenerative Medicine." Int. J. Mol. Sci. 13, no. 3: 3847-3886.

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