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Int. J. Mol. Sci. 2012, 13(3), 3887-3899; doi:10.3390/ijms13033887
Article

Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents

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1 Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil 2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil 3 Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora 36036-330, Brazil
* Author to whom correspondence should be addressed.
Received: 26 December 2011 / Revised: 2 March 2012 / Accepted: 19 March 2012 / Published: 22 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.
Keywords: Vernonia polyanthes; antinociceptive effect; anti-inflammatory effect Vernonia polyanthes; antinociceptive effect; anti-inflammatory effect
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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dos Santos Temponi, V.; da Silva, J.B.; Alves, M.S.; Ribeiro, A.; Pinho, J.J.R.G.; Yamamoto, C.H.; Pinto, M.A.O.; Del-Vechio-Vieira, G.; de Sousa, O.V. Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents. Int. J. Mol. Sci. 2012, 13, 3887-3899.

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