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Int. J. Mol. Sci. 2012, 13(3), 3887-3899; doi:10.3390/ijms13033887
Article

Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents

1
, 1
, 2
, 3
, 2
, 2
, 2
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 and 2,*
1 Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil 2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil 3 Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora 36036-330, Brazil
* Author to whom correspondence should be addressed.
Received: 26 December 2011 / Revised: 2 March 2012 / Accepted: 19 March 2012 / Published: 22 March 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.
Keywords: Vernonia polyanthes; antinociceptive effect; anti-inflammatory effect Vernonia polyanthes; antinociceptive effect; anti-inflammatory effect
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

dos Santos Temponi, V.; da Silva, J.B.; Alves, M.S.; Ribeiro, A.; Pinho, J.J.R.G.; Yamamoto, C.H.; Pinto, M.A.O.; Del-Vechio-Vieira, G.; de Sousa, O.V. Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents. Int. J. Mol. Sci. 2012, 13, 3887-3899.

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