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Int. J. Mol. Sci. 2012, 13(2), 2405-2424; doi:10.3390/ijms13022405

Characterization of Different Functionalized Lipidic Nanocapsules as Potential Drug Carriers

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Received: 21 December 2011 / Revised: 14 February 2012 / Accepted: 15 February 2012 / Published: 22 February 2012
(This article belongs to the Special Issue From Molecules to Nanomaterials)
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Abstract: Lipid nanocapsules (LNC) based on a core-shell structure consisting of an oil-filled core with a surrounding polymer layer are known to be promising vehicles for the delivery of hydrophobic drugs in the new therapeutic strategies in anti-cancer treatments. The present work has been designed as basic research about different LNC systems. We have synthesized—and physico-chemically characterized—three different LNC systems in which the core was constituted by olive oil and the shell by different phospholipids (phosphatidyl-serine or lecithin) and other biocompatible molecules such as Pluronic® F68 or chitosan. It is notable that the olive-oil-phosphatidyl-serine LCN is a novel formulation presented in this work and was designed to generate an enriched carboxylic surface. This carboxylic layer is meant to link specific antibodies, which could facilitate the specific nanocapsule uptake by cancer cells. This is why nanoparticles with phosphatidyl-serine in their shell have also been used in this work to form immuno-nanocapsules containing a polyclonal IgG against a model antigen (C-reactive protein) covalently bounded by means of a simple and reproducible carbodiimide method. An immunological study was made to verify that these IgG-LNC complexes showed the expected specific immune response. Finally, a preliminary in vitro study was performed by culturing a breast-carcinoma cell line (MCF-7) with Nile-Red-loaded LNC. We found that these cancer cells take up the fluorescent Nile-Red molecule in a process dependent on the surface properties of the nanocarriers.
Keywords: nanocarriers; lipid nanocapsules; immuno-nanocapsules; drug delivery nanocarriers; lipid nanocapsules; immuno-nanocapsules; drug delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sánchez-Moreno, P.; Ortega-Vinuesa, J.L.; Martín-Rodríguez, A.; Boulaiz, H.; Marchal-Corrales, J.A.; Peula-García, J.M. Characterization of Different Functionalized Lipidic Nanocapsules as Potential Drug Carriers. Int. J. Mol. Sci. 2012, 13, 2405-2424.

AMA Style

Sánchez-Moreno P, Ortega-Vinuesa JL, Martín-Rodríguez A, Boulaiz H, Marchal-Corrales JA, Peula-García JM. Characterization of Different Functionalized Lipidic Nanocapsules as Potential Drug Carriers. International Journal of Molecular Sciences. 2012; 13(2):2405-2424.

Chicago/Turabian Style

Sánchez-Moreno, Paola; Ortega-Vinuesa, Juan Luis; Martín-Rodríguez, Antonio; Boulaiz, Houría; Marchal-Corrales, Juan Antonio; Peula-García, José Manuel. 2012. "Characterization of Different Functionalized Lipidic Nanocapsules as Potential Drug Carriers." Int. J. Mol. Sci. 13, no. 2: 2405-2424.

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