Int. J. Mol. Sci. 2012, 13(3), 3414-3430; doi:10.3390/ijms13033414
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Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions

1 Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan 2 Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan
* Authors to whom correspondence should be addressed.
Received: 11 January 2012; in revised form: 25 January 2012 / Accepted: 23 February 2012 / Published: 12 March 2012
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Abstract: Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed.
Keywords: axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein

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MDPI and ACS Style

Goshima, Y.; Hida, T.; Gotoh, T. Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions. Int. J. Mol. Sci. 2012, 13, 3414-3430.

AMA Style

Goshima Y, Hida T, Gotoh T. Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions. International Journal of Molecular Sciences. 2012; 13(3):3414-3430.

Chicago/Turabian Style

Goshima, Yoshio; Hida, Tomonobu; Gotoh, Toshiyuki. 2012. "Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions." Int. J. Mol. Sci. 13, no. 3: 3414-3430.

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