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• Hida, T
• Gotoh, T
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• Hida, T
• Gotoh, T
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• Hida, T
• Gotoh, T

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Int. J. Mol. Sci. 2012, 13(3), 3414-3430; doi:10.3390/ijms13033414

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Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions

Yoshio Goshima ^1,* , Tomonobu Hida ¹  and Toshiyuki Gotoh ^2,*

¹ Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan ² Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan

* Authors to whom correspondence should be addressed.

Received: 11 January 2012; in revised form: 25 January 2012 / Accepted: 23 February 2012 / Published: 12 March 2012

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Abstract: Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed.

Keywords: axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein

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