Next Article in Journal
Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats
Previous Article in Journal
Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2012, 13(3), 3414-3430; doi:10.3390/ijms13033414

Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions

1
Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan
2
Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan
*
Authors to whom correspondence should be addressed.
Received: 11 January 2012 / Revised: 25 January 2012 / Accepted: 23 February 2012 / Published: 12 March 2012
View Full-Text   |   Download PDF [328 KB, uploaded 19 June 2014]   |  

Abstract

Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed.
Keywords: axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Goshima, Y.; Hida, T.; Gotoh, T. Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions. Int. J. Mol. Sci. 2012, 13, 3414-3430.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top