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Int. J. Mol. Sci. 2012, 13(3), 3414-3430; doi:10.3390/ijms13033414
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Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions

1,* , 1
 and
2,*
1 Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan 2 Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan
* Authors to whom correspondence should be addressed.
Received: 11 January 2012 / Revised: 25 January 2012 / Accepted: 23 February 2012 / Published: 12 March 2012
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Abstract

Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed.
Keywords: axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein axonal transport; anti-neoplastic agents; microtubules; kinesin; dynein
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Goshima, Y.; Hida, T.; Gotoh, T. Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development and Functions. Int. J. Mol. Sci. 2012, 13, 3414-3430.

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