Next Article in Journal
Chemical Composition and Antimicrobial Activity of the Essential Oil of Kumquat (Fortunella crassifolia Swingle) Peel
Next Article in Special Issue
Cooperative Modulation of Mineral Growth by Prismatic-Associated Asprich Sequences and Mg(II)
Previous Article in Journal
The Hypoglycemic Effect of the Kelp on Diabetes Mellitus Model Induced by Alloxan in Rats
Previous Article in Special Issue
Enhancing Osteoconduction of PLLA-Based Nanocomposite Scaffolds for Bone Regeneration Using Different Biomimetic Signals to MSCs
Int. J. Mol. Sci. 2012, 13(3), 3366-3381; doi:10.3390/ijms13033366
Article

Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents

1
, 1,* , 1
 and 2
Received: 1 December 2011; in revised form: 4 January 2012 / Accepted: 20 February 2012 / Published: 12 March 2012
(This article belongs to the Special Issue Composite Materials in Skeletal Engineering)
View Full-Text   |   Download PDF [630 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: In this study, vascular stents were fabricated from poly (lactide-ε-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycapr-olactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.
Keywords: nano-composite scaffold; tissue engineering; mechanical property; electrospinning nano-composite scaffold; tissue engineering; mechanical property; electrospinning
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Xu, H.; Su, J.; Sun, J.; Ren, T. Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents. Int. J. Mol. Sci. 2012, 13, 3366-3381.

AMA Style

Xu H, Su J, Sun J, Ren T. Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents. International Journal of Molecular Sciences. 2012; 13(3):3366-3381.

Chicago/Turabian Style

Xu, Hongzhen; Su, Jiansheng; Sun, Jun; Ren, Tianbin. 2012. "Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents." Int. J. Mol. Sci. 13, no. 3: 3366-3381.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert