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Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents
Institute of Prosthodontics , School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China
Institute of Nano- and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China
* Author to whom correspondence should be addressed.
Received: 1 December 2011; in revised form: 4 January 2012 / Accepted: 20 February 2012 / Published: 12 March 2012
Abstract: In this study, vascular stents were fabricated from poly (lactide-ε-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycapr-olactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.
Keywords: nano-composite scaffold; tissue engineering; mechanical property; electrospinning
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Xu, H.; Su, J.; Sun, J.; Ren, T. Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents. Int. J. Mol. Sci. 2012, 13, 3366-3381.
Xu H, Su J, Sun J, Ren T. Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents. International Journal of Molecular Sciences. 2012; 13(3):3366-3381.
Xu, Hongzhen; Su, Jiansheng; Sun, Jun; Ren, Tianbin. 2012. "Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents." Int. J. Mol. Sci. 13, no. 3: 3366-3381.