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Int. J. Mol. Sci. 2012, 13(3), 3366-3381; doi:10.3390/ijms13033366

Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents

1,* , 1
1 Institute of Prosthodontics , School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China 2 Institute of Nano- and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China
* Author to whom correspondence should be addressed.
Received: 1 December 2011 / Revised: 4 January 2012 / Accepted: 20 February 2012 / Published: 12 March 2012
(This article belongs to the Special Issue Composite Materials in Skeletal Engineering)
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In this study, vascular stents were fabricated from poly (lactide-ε-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycapr-olactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.
Keywords: nano-composite scaffold; tissue engineering; mechanical property; electrospinning nano-composite scaffold; tissue engineering; mechanical property; electrospinning
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, H.; Su, J.; Sun, J.; Ren, T. Preparation and Characterization of New Nano-Composite Scaffolds Loaded With Vascular Stents. Int. J. Mol. Sci. 2012, 13, 3366-3381.

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