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Int. J. Mol. Sci. 2012, 13(3), 2965-2972; doi:10.3390/ijms13032965

Management of Diabetes Mellitus: Could Simultaneous Targeting of Hyperglycemia and Oxidative Stress Be a Better Panacea?

Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Received: 16 November 2011 / Revised: 23 January 2012 / Accepted: 29 January 2012 / Published: 6 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The primary aim of the current management of diabetes mellitus is to achieve and/or maintain a glycated hemoglobin level of ≤6.5%. However, recent evidence indicates that intensive treatment of hyperglycemia is characterized by increased weight gain, severe hypoglycemia and higher mortality. Besides, evidence suggests that it is difficult to achieve and/or maintain optimal glycemic control in many diabetic patients; and that the benefits of intensively-treated hyperglycemia are restricted to microvascular complications only. In view of these adverse effects and limitations of intensive treatment of hyperglycemia in preventing diabetic complications, which is linked to oxidative stress, this commentary proposes a hypothesis that “simultaneous targeting of hyperglycemia and oxidative stress” could be more effective than “intensive treatment of hyperglycemia” in the management of diabetes mellitus.
Keywords: hyperglycemia; intensive therapy; glycemic control; hypoglycemic drugs; oxidative stress; antioxidants hyperglycemia; intensive therapy; glycemic control; hypoglycemic drugs; oxidative stress; antioxidants
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Erejuwa, O.O. Management of Diabetes Mellitus: Could Simultaneous Targeting of Hyperglycemia and Oxidative Stress Be a Better Panacea? Int. J. Mol. Sci. 2012, 13, 2965-2972.

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