Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
Abstract
:1. Introduction
2. Chemokine Expressions in the CNS
3. Transplanted Neural Cells and Chemokines
4. Neural Stem/Progenitor Cells and Neural Cell Associated Adhesion Molecules
5. Conclusions
Supplementary Material
ijms-13-02636-s001.pdfReferences
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Chemokine | Receptor | Distribution |
---|---|---|
Physiological | ||
In vivo | ||
MCP1/CCL2 | CCR2 | Fetal and adult brain: Neurons [21] |
CTACK/CCL27 | CCR10 | Adult brain: Neurons [22] |
SDF1/CXCL12 | CXCR4 | Adult brain: Neurons [23] |
Fractalkine/CX3CL1 | CX3CR1 | Adult brain: Astrocytes [24] |
In vitro | ||
MCP1/CCL2 | CCR2 | Primary astrocyte culture [25] |
MIP1α/CCL3 | CCR3 | Primary astrocyte culture [25] |
MIP1β/CCL4 | CCR5 | Primary astrocyte culture [25] |
RANTES/CCL5 | CCR5 | Primary astrocyte culture [25] |
SDF1/CXCL12 | CXCR4 | Primary fetal neural cell culture [23] |
Fractalkine/CX3CL1 | CX3CR1 | Primary neural and glial cell culture [26] |
Pathological | ||
MCP1/CCL2 | CCR2 | Astrocytes in HIV encephalitis [27] |
RANTES/CCL5 | CCR5 | Astrocytes in HIV encephalitis [27] |
IP10/CXCL10 | CXCR3 | Neurons in HIV encephalitis [28] |
SDF1/CXCL12 | CXCR4 | Neurons and Astrocytes in AIDS dementia [23] |
Fractalkine/CX3CL1 | CX3CR1 | Astrocytes in multiple sclerosis [24] Neurons in HIV encephalitis [29] |
Chemokine | Receptor | Target Cells |
---|---|---|
Cell Migration | ||
RANTES/CCL5 | CCR5 | Neurons [30] |
SDF1/CXCL12 | CXCR4 | Cerebellar granule neurons [31] Cortical neural progenitors [32] Dentate gyrus granular neurons [33] |
MCP1/CCL2 | CCR2 | Astrocytes [34] |
Cell Proliferation | ||
MIP1α/CCL3 | CCR3 | Astrocytes [34] |
RANTES/CCL5 | CCR5 | Astrocytes [25] |
GROα/CXCL1 | CXCR2 | Astrocytes, Oligodendrocyte precursors [35] |
SDF1/CXCL12 | CXCR4 | Astrocytes [36,37] |
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Arimitsu, N.; Shimizu, J.; Fujiwara, N.; Takai, K.; Takada, E.; Kono, T.; Ueda, Y.; Suzuki, T.; Suzuki, N. Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation. Int. J. Mol. Sci. 2012, 13, 2636-2649. https://doi.org/10.3390/ijms13032636
Arimitsu N, Shimizu J, Fujiwara N, Takai K, Takada E, Kono T, Ueda Y, Suzuki T, Suzuki N. Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation. International Journal of Molecular Sciences. 2012; 13(3):2636-2649. https://doi.org/10.3390/ijms13032636
Chicago/Turabian StyleArimitsu, Nagisa, Jun Shimizu, Naruyoshi Fujiwara, Kenji Takai, Erika Takada, Takao Kono, Yuji Ueda, Tomoko Suzuki, and Noboru Suzuki. 2012. "Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation" International Journal of Molecular Sciences 13, no. 3: 2636-2649. https://doi.org/10.3390/ijms13032636