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Int. J. Mol. Sci. 2012, 13(3), 2636-2649; doi:10.3390/ijms13032636

Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

1
Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan
2
Department of Neurosurgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan
*
Author to whom correspondence should be addressed.
Received: 1 December 2011 / Revised: 8 February 2012 / Accepted: 14 February 2012 / Published: 28 February 2012
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Abstract

Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models. View Full-Text
Keywords: neural stem/progenitor cells; chemokines; cell migration; chemokine receptor neural stem/progenitor cells; chemokines; cell migration; chemokine receptor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Arimitsu, N.; Shimizu, J.; Fujiwara, N.; Takai, K.; Takada, E.; Kono, T.; Ueda, Y.; Suzuki, T.; Suzuki, N. Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation. Int. J. Mol. Sci. 2012, 13, 2636-2649.

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