Open AccessThis article is
- freely available
Impaired Iron Status in Aging Research
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA
Biology Institute, Hebei Academy of Science, Shijiazhuang 050051, China
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
* Authors to whom correspondence should be addressed.
Received: 17 November 2011; in revised form: 18 February 2012 / Accepted: 20 February 2012 / Published: 22 February 2012
Abstract: Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
Keywords: labile iron; iron accumulation; oxidative damage; mitochondrial dysfunction; aging
Citations to this Article
Cite This Article
MDPI and ACS Style
Xu, J.; Jia, Z.; Knutson, M.D.; Leeuwenburgh, C. Impaired Iron Status in Aging Research. Int. J. Mol. Sci. 2012, 13, 2368-2386.
Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired Iron Status in Aging Research. International Journal of Molecular Sciences. 2012; 13(2):2368-2386.
Xu, Jinze; Jia, Zhenhua; Knutson, Mitchell D.; Leeuwenburgh, Christiaan. 2012. "Impaired Iron Status in Aging Research." Int. J. Mol. Sci. 13, no. 2: 2368-2386.