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Impaired Iron Status in Aging Research
AbstractAging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
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Xu, J.; Jia, Z.; Knutson, M.D.; Leeuwenburgh, C. Impaired Iron Status in Aging Research. Int. J. Mol. Sci. 2012, 13, 2368-2386.View more citation formats
Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired Iron Status in Aging Research. International Journal of Molecular Sciences. 2012; 13(2):2368-2386.Chicago/Turabian Style
Xu, Jinze; Jia, Zhenhua; Knutson, Mitchell D.; Leeuwenburgh, Christiaan. 2012. "Impaired Iron Status in Aging Research." Int. J. Mol. Sci. 13, no. 2: 2368-2386.