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Int. J. Mol. Sci. 2012, 13(2), 2368-2386; doi:10.3390/ijms13022368

Impaired Iron Status in Aging Research

1
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA
2
Biology Institute, Hebei Academy of Science, Shijiazhuang 050051, China
3
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
*
Authors to whom correspondence should be addressed.
Received: 17 November 2011 / Revised: 18 February 2012 / Accepted: 20 February 2012 / Published: 22 February 2012
(This article belongs to the Special Issue Oxidative Stress and Mitochondria)
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Abstract

Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models. View Full-Text
Keywords: labile iron; iron accumulation; oxidative damage; mitochondrial dysfunction; aging labile iron; iron accumulation; oxidative damage; mitochondrial dysfunction; aging
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xu, J.; Jia, Z.; Knutson, M.D.; Leeuwenburgh, C. Impaired Iron Status in Aging Research. Int. J. Mol. Sci. 2012, 13, 2368-2386.

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