Int. J. Mol. Sci. 2012, 13(2), 2368-2386; doi:10.3390/ijms13022368
Review

Impaired Iron Status in Aging Research

1,* email, 2email, 3email and 1,* email
Received: 17 November 2011; in revised form: 18 February 2012 / Accepted: 20 February 2012 / Published: 22 February 2012
(This article belongs to the Special Issue Oxidative Stress and Mitochondria)
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Abstract: Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
Keywords: labile iron; iron accumulation; oxidative damage; mitochondrial dysfunction; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xu, J.; Jia, Z.; Knutson, M.D.; Leeuwenburgh, C. Impaired Iron Status in Aging Research. Int. J. Mol. Sci. 2012, 13, 2368-2386.

AMA Style

Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired Iron Status in Aging Research. International Journal of Molecular Sciences. 2012; 13(2):2368-2386.

Chicago/Turabian Style

Xu, Jinze; Jia, Zhenhua; Knutson, Mitchell D.; Leeuwenburgh, Christiaan. 2012. "Impaired Iron Status in Aging Research." Int. J. Mol. Sci. 13, no. 2: 2368-2386.


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