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Int. J. Mol. Sci. 2012, 13(2), 1762-1777; doi:10.3390/ijms13021762
Article

10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer

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Received: 22 December 2011; in revised form: 9 January 2012 / Accepted: 13 January 2012 / Published: 8 February 2012
(This article belongs to the Special Issue Antioxidants)
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Abstract: In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Keywords: ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, C.-Y.; Cheng, K.-C.; Chang, A.Y.; Lin, Y.-T.; Hseu, Y.-C.; Wang, H.-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int. J. Mol. Sci. 2012, 13, 1762-1777.

AMA Style

Chen C-Y, Cheng K-C, Chang AY, Lin Y-T, Hseu Y-C, Wang H-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 2012; 13(2):1762-1777.

Chicago/Turabian Style

Chen, Chung-Yi; Cheng, Kuo-Chen; Chang, Andy Y; Lin, Ying-Ting; Hseu, You-Cheng; Wang, Hui-Min. 2012. "10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer." Int. J. Mol. Sci. 13, no. 2: 1762-1777.


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