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Int. J. Mol. Sci. 2012, 13(2), 1762-1777; doi:10.3390/ijms13021762
Article

10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer

1
,
2,3,4
,
5,6
,
7
,
8
 and
6,*
1 Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan 2 Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan 3 Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan 4 Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan 5 Department of Biology, University of California, Riverside, Riverside, CA 92521, USA 6 Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan 7 Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 8 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 December 2011 / Revised: 9 January 2012 / Accepted: 13 January 2012 / Published: 8 February 2012
(This article belongs to the Special Issue Antioxidants)
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Abstract

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Keywords: ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chen, C.-Y.; Cheng, K.-C.; Chang, A.Y.; Lin, Y.-T.; Hseu, Y.-C.; Wang, H.-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int. J. Mol. Sci. 2012, 13, 1762-1777.

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