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Int. J. Mol. Sci. 2012, 13(2), 1762-1777; doi:10.3390/ijms13021762
Article

10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer

1
, 2,3,4
, 5,6
, 7
, 8
 and 6,*
1 Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan 2 Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan 3 Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan 4 Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan 5 Department of Biology, University of California, Riverside, Riverside, CA 92521, USA 6 Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan 7 Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 8 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 December 2011 / Revised: 9 January 2012 / Accepted: 13 January 2012 / Published: 8 February 2012
(This article belongs to the Special Issue Antioxidants)
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Abstract

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Keywords: ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, C.-Y.; Cheng, K.-C.; Chang, A.Y.; Lin, Y.-T.; Hseu, Y.-C.; Wang, H.-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int. J. Mol. Sci. 2012, 13, 1762-1777.

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