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10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer
Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan
Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan
Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan
Department of Biology, University of California, Riverside, Riverside, CA 92521, USA
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan
Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 December 2011; in revised form: 9 January 2012 / Accepted: 13 January 2012 / Published: 8 February 2012
Abstract: In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
Keywords: ginger; 10-shogaol; antioxidant activities; skin cell; proliferation; growth factors; migration
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MDPI and ACS Style
Chen, C.-Y.; Cheng, K.-C.; Chang, A.Y.; Lin, Y.-T.; Hseu, Y.-C.; Wang, H.-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int. J. Mol. Sci. 2012, 13, 1762-1777.
Chen C-Y, Cheng K-C, Chang AY, Lin Y-T, Hseu Y-C, Wang H-M. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. International Journal of Molecular Sciences. 2012; 13(2):1762-1777.
Chen, Chung-Yi; Cheng, Kuo-Chen; Chang, Andy Y; Lin, Ying-Ting; Hseu, You-Cheng; Wang, Hui-Min. 2012. "10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer." Int. J. Mol. Sci. 13, no. 2: 1762-1777.