Int. J. Mol. Sci. 2012, 13(12), 17210-17229; doi:10.3390/ijms131217210

X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair

1, 1, 2email and 1,* email
Received: 9 November 2012; in revised form: 6 December 2012 / Accepted: 7 December 2012 / Published: 17 December 2012
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways. XRCC1 also interacts with itself and rapidly accumulates at sites of DNA damage. XRCC1 can thus mediate the assembly of large multiprotein DNA repair complexes as well as facilitate the recruitment of DNA repair proteins to sites of DNA damage. Moreover, XRCC1 is present in constitutive DNA repair complexes, some of which associate with the replication machinery. Because of the critical role of XRCC1 in DNA repair, its common variants Arg194Trp, Arg280His and Arg399Gln have been extensively studied. However, the prevalence of these variants varies strongly in different populations, and their functional influence on DNA repair and disease remains elusive. Here we present the current knowledge about the role of XRCC1 and its variants in BER and human disease/cancer.
Keywords: BER; XRCC1; disease; DNA damage; polymorphisms; recruitment; repair complex; scaffold
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MDPI and ACS Style

Hanssen-Bauer, A.; Solvang-Garten, K.; Akbari, M.; Otterlei, M. X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair. Int. J. Mol. Sci. 2012, 13, 17210-17229.

AMA Style

Hanssen-Bauer A, Solvang-Garten K, Akbari M, Otterlei M. X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair. International Journal of Molecular Sciences. 2012; 13(12):17210-17229.

Chicago/Turabian Style

Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit. 2012. "X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair." Int. J. Mol. Sci. 13, no. 12: 17210-17229.

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