Int. J. Mol. Sci. 2012, 13(12), 16598-16623; doi:10.3390/ijms131216598
Review

Recent Advances in Nanoparticle-Based Förster Resonance Energy Transfer for Biosensing, Molecular Imaging and Drug Release Profiling

Nai-Tzu Chen 1,2 email, Shih-Hsun Cheng 1,3 email, Ching-Ping Liu 1 email, Jeffrey S. Souris 3 email, Chen-Tu Chen 3 email, Chung-Yuan Mou 2 email and Leu-Wei Lo 1,* email
1 Division of Medical Engineering Research, National Health Research Institutes, Zhunan 35053, Miaoli County, Taiwan 2 Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan 3 Department of Radiology, The University of Chicago, Chicago, IL 60637, USA
* Author to whom correspondence should be addressed.
Received: 11 October 2012; in revised form: 15 November 2012 / Accepted: 16 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Förster Resonance Energy Transfer (FRET))
PDF Full-text Download PDF Full-Text [1637 KB, uploaded 5 December 2012 10:28 CET]
Abstract: Förster resonance energy transfer (FRET) may be regarded as a “smart” technology in the design of fluorescence probes for biological sensing and imaging. Recently, a variety of nanoparticles that include quantum dots, gold nanoparticles, polymer, mesoporous silica nanoparticles and upconversion nanoparticles have been employed to modulate FRET. Researchers have developed a number of “visible” and “activatable” FRET probes sensitive to specific changes in the biological environment that are especially attractive from the biomedical point of view. This article reviews recent progress in bringing these nanoparticle-modulated energy transfer schemes to fruition for applications in biosensing, molecular imaging and drug delivery.
Keywords: Förster resonance energy transfer; FRET; nanoparticle; biosensing; molecular imaging; drug controlled release; quantum dots; gold nanoparticles; mesoporous silica nanoparticles; upconversion nanoparticle

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Chen, N.-T.; Cheng, S.-H.; Liu, C.-P.; Souris, J.S.; Chen, C.-T.; Mou, C.-Y.; Lo, L.-W. Recent Advances in Nanoparticle-Based Förster Resonance Energy Transfer for Biosensing, Molecular Imaging and Drug Release Profiling. Int. J. Mol. Sci. 2012, 13, 16598-16623.

AMA Style

Chen N-T, Cheng S-H, Liu C-P, Souris JS, Chen C-T, Mou C-Y, Lo L-W. Recent Advances in Nanoparticle-Based Förster Resonance Energy Transfer for Biosensing, Molecular Imaging and Drug Release Profiling. International Journal of Molecular Sciences. 2012; 13(12):16598-16623.

Chicago/Turabian Style

Chen, Nai-Tzu; Cheng, Shih-Hsun; Liu, Ching-Ping; Souris, Jeffrey S.; Chen, Chen-Tu; Mou, Chung-Yuan; Lo, Leu-Wei. 2012. "Recent Advances in Nanoparticle-Based Förster Resonance Energy Transfer for Biosensing, Molecular Imaging and Drug Release Profiling." Int. J. Mol. Sci. 13, no. 12: 16598-16623.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert