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DNA Damage and Repair in Epithelium after Allogeneic Hematopoietic Stem Cell Transplantation
Hematology Division, BMT Unit, University Hospital of Patras, Rio 26500, Greece
Current address: Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
* Author to whom correspondence should be addressed.
Received: 19 October 2012; in revised form: 18 November 2012 / Accepted: 19 November 2012 / Published: 27 November 2012
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) in humans, following hematoablative treatment, results in biological chimeras. In this case, the transplanted hematopoietic, immune cells and their derivatives can be considered the donor genotype, while the other tissues are the recipient genotype. The first sequel, which has been recognized in the development of chimerical organisms after allo-HSCT, is the graft versus host (GvH) reaction, in which the new developed immune cells from the graft recognize the host’s epithelial cells as foreign and mount an inflammatory response to kill them. There is now accumulating evidence that this chronic inflammatory tissue stress may contribute to clinical consequences in the transplant recipient. It has been recently reported that host epithelial tissue acquire genomic alterations and display a mutator phenotype that may be linked to the occurrence of a GvH reaction. The current review discusses existing data on this recently discovered phenomenon and focuses on the possible pathogenesis, clinical significance and therapeutic implications.
Keywords: bone marrow transplantation; mismatch repair; microsatellite instability; graft-versus-host reaction
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Themeli, M.; Spyridonidis, A. DNA Damage and Repair in Epithelium after Allogeneic Hematopoietic Stem Cell Transplantation. Int. J. Mol. Sci. 2012, 13, 15813-15825.
Themeli M, Spyridonidis A. DNA Damage and Repair in Epithelium after Allogeneic Hematopoietic Stem Cell Transplantation. International Journal of Molecular Sciences. 2012; 13(12):15813-15825.
Themeli, Maria; Spyridonidis, Alexandros. 2012. "DNA Damage and Repair in Epithelium after Allogeneic Hematopoietic Stem Cell Transplantation." Int. J. Mol. Sci. 13, no. 12: 15813-15825.