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Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Graduate School of Chinese Academy of Sciences, Beijing 100039, China
* Author to whom correspondence should be addressed.
Received: 22 September 2012; in revised form: 24 October 2012 / Accepted: 31 October 2012 / Published: 14 November 2012
Abstract: Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
Keywords: Myostatin (MSTN); single nucleotide polymorphisms (SNPs); common carp (Cyprinus carpio L.); growth traits; association analysis
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MDPI and ACS Style
Sun, Y.; Yu, X.; Tong, J. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.). Int. J. Mol. Sci. 2012, 13, 14956-14961.
Sun Y, Yu X, Tong J. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.). International Journal of Molecular Sciences. 2012; 13(11):14956-14961.
Sun, Yanhong; Yu, Xiaomu; Tong, Jingou. 2012. "Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)." Int. J. Mol. Sci. 13, no. 11: 14956-14961.