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Int. J. Mol. Sci. 2012, 13(11), 14956-14961; doi:10.3390/ijms131114956
Technical Note

Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)

1,2
, 1
 and 1,*
Received: 22 September 2012; in revised form: 24 October 2012 / Accepted: 31 October 2012 / Published: 14 November 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp.
Keywords: Myostatin (MSTN); single nucleotide polymorphisms (SNPs); common carp (Cyprinus carpio L.); growth traits; association analysis Myostatin (MSTN); single nucleotide polymorphisms (SNPs); common carp (Cyprinus carpio L.); growth traits; association analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sun, Y.; Yu, X.; Tong, J. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.). Int. J. Mol. Sci. 2012, 13, 14956-14961.

AMA Style

Sun Y, Yu X, Tong J. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.). International Journal of Molecular Sciences. 2012; 13(11):14956-14961.

Chicago/Turabian Style

Sun, Yanhong; Yu, Xiaomu; Tong, Jingou. 2012. "Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)." Int. J. Mol. Sci. 13, no. 11: 14956-14961.


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