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Int. J. Mol. Sci. 2012, 13(11), 14845-14864; doi:10.3390/ijms131114845
Review

The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer

 and *
Received: 18 September 2012; in revised form: 16 October 2012 / Accepted: 1 November 2012 / Published: 13 November 2012
(This article belongs to the Special Issue Advances in Molecular Oncology)
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Abstract: Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy.
Keywords: angiogenesis; breast cancer; polymorphism; vascular endothelial growth factor angiogenesis; breast cancer; polymorphism; vascular endothelial growth factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sa-nguanraksa, D.; O-charoenrat, P. The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer. Int. J. Mol. Sci. 2012, 13, 14845-14864.

AMA Style

Sa-nguanraksa D, O-charoenrat P. The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer. International Journal of Molecular Sciences. 2012; 13(11):14845-14864.

Chicago/Turabian Style

Sa-nguanraksa, Doonyapat; O-charoenrat, Pornchai. 2012. "The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer." Int. J. Mol. Sci. 13, no. 11: 14845-14864.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert