Next Article in Journal
Previous Article in Journal
Int. J. Mol. Sci. 2012, 13(11), 14813-14827; doi:10.3390/ijms131114813
Article

The Murine PSE/TATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart

1
, 2
, 1
, 1
, 1
, 3
, 3
, 1,4
 and 1,4,*
Received: 25 September 2012; in revised form: 23 October 2012 / Accepted: 25 October 2012 / Published: 13 November 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [323 KB, uploaded 19 June 2014]
Abstract: A series of recent studies demonstrated an unexpectedly high frequency of intronic RNA polymerase (pol) III transcription units spread throughout the human genome. The investigation of a subset of these transcripts revealed their tissue/cell-specific transcription together with the involvement in relevant physiopathological pathways. Despite this evidence, these transcripts did not seem to have murine orthologs, based on their nucleotide sequence, resulting in a limitation of the experimental approaches aimed to study their function. In this work, we have extended our investigation to the murine genome identifying 121 pairs of mouse/human transcripts displaying syntenic subchromosomal localization. The analysis in silico of this set of putative noncoding (nc)RNAs suggest their association with alternative splicing as suggested by recent experimental evidence. The investigation of one of these pairs taken as experimental model in mouse hippocampal neurons provided evidence of a human/mouse functional homology that does not depend on underlying sequence conservation. In this light, the collection of transcriptional units here reported can be considered as a novel source for the identification and the study of novel regulatory elements involved in relevant biological processes.
Keywords: RNA polymerase III; alternative splicing; non-coding RNA; potassium channel interacting protein (KCNIP4) RNA polymerase III; alternative splicing; non-coding RNA; potassium channel interacting protein (KCNIP4)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Bruzzone, M.J.; Gavazzo, P.; Massone, S.; Balbi, C.; Villa, F.; Conti, A.; Dieci, G.; Cancedda, R.; Pagano, A. The Murine PSE/TATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart. Int. J. Mol. Sci. 2012, 13, 14813-14827.

AMA Style

Bruzzone MJ, Gavazzo P, Massone S, Balbi C, Villa F, Conti A, Dieci G, Cancedda R, Pagano A. The Murine PSE/TATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart. International Journal of Molecular Sciences. 2012; 13(11):14813-14827.

Chicago/Turabian Style

Bruzzone, Maria J.; Gavazzo, Paola; Massone, Sara; Balbi, Carolina; Villa, Federico; Conti, Anastasia; Dieci, Giorgio; Cancedda, Ranieri; Pagano, Aldo. 2012. "The Murine PSE/TATA-Dependent Transcriptome: Evidence of Functional Homologies with Its Human Counterpart." Int. J. Mol. Sci. 13, no. 11: 14813-14827.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert