Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice
Abstract
:1. Introduction
2. Results and Discussion
2.1. Method of Plasma Samples Qualification
2.2. Method of Brain Samples Qualification
2.3. Statistical Analysis and Pharmacokinetics
3. Experimental
3.1. Chemicals, Reagents and Animals
3.2. Instrumentation
3.3. Chromatographic Conditions
3.4. Sample Preparation
3.4.1. Solution Preparation
3.4.2. In Vivo Experiments
3.5. Statistical Evaluation
4. Conclusions
Acknowledgements
References
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Group | Parameters | ||||
---|---|---|---|---|---|
Cmax (μg/mL) | Tmax (min) | AUC0–120 (μg/mL·min) | MRT0–120 (min) | F (%) | |
i.v. | 42.410 ± 6.268 | - | 324.88 ± 37.62 | 15.01 ± 1.49 | 100 |
i.n. | 21.881 ± 5.398 ** | 1 | 277.39 ± 22.65 * | 31.70 ± 5.68 ** | 85.38 |
i.g. | 1.914 ± 0.327 ** | 30 | 93.44 ± 9.71 ** | 42.03 ± 6.63 ** | 28.76 |
Group | Parameters | ||||||
---|---|---|---|---|---|---|---|
Cmax (ng/g) | Tmax (min) | AUC0–120 (ng/g·min) | MRTlast (min) | Re (%) | Te (%) | DTI | |
i.v. | 1476.4 ± 145.1 | 1 | 37270.5 ± 4160.6 | 48.3 ± 2.0 | 100 | 11.47 | 1 |
i.n. | 746.7 ± 174.8 ** | 3 | 32413.6 ± 4573.9 | 51.2 ± 2.6 | 86.97 | 11.69 | 1.02 |
i.g. | 76.2 ± 22.1 ** | 60 ** | 6440.1 ± 863.7 ** | 60.0 ± 3.4 ** | 17.28 ** | 6.89 ** | 0.60 ** |
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Lu, Y.; Du, S.; Bai, J.; Li, P.; Wen, R.; Zhao, X. Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice. Int. J. Mol. Sci. 2012, 13, 14127-14135. https://doi.org/10.3390/ijms131114127
Lu Y, Du S, Bai J, Li P, Wen R, Zhao X. Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice. International Journal of Molecular Sciences. 2012; 13(11):14127-14135. https://doi.org/10.3390/ijms131114127
Chicago/Turabian StyleLu, Yang, Shouying Du, Jie Bai, Pengyue Li, Ran Wen, and Xuejiao Zhao. 2012. "Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice" International Journal of Molecular Sciences 13, no. 11: 14127-14135. https://doi.org/10.3390/ijms131114127