Int. J. Mol. Sci. 2012, 13(10), 13737-13747; doi:10.3390/ijms131013737
Review

The Criteria to Confirm the Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma Initiation

1,2email, 1email and 1,3,* email
Received: 5 September 2012; in revised form: 16 October 2012 / Accepted: 17 October 2012 / Published: 23 October 2012
(This article belongs to the Special Issue Advances in Molecular Oncology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC), but it remains obscure whether EBV is a viral cause of, or only an accompaniment of, NPC. We will discuss the accumulated evidence pointing to the relationship between EBV infection and NPC initiation from epidemiologic, pathogenic, molecular oncogenic, and experimental animal studies. We believe that convincing evidence from these perspectives must be provided before we can ascertain the causal role of EBV infection in NPC. Specifically, (1) epidemiological studies should reveal EBV infection as a risk factor; (2) the introduction of EBV into an animal model should produce NPC; (3) in the animal model NPC, the main molecular event(s) or the involved signaling pathway(s) should be identical to that in human NPC; and (4) finally and most importantly, prevention of EBV infection or clearance of EBV from infected individuals must be able to reduce the incidence rate of NPC.
Keywords: Epstein-Barr virus; nasopharyngeal carcinoma; tumorigenesis; infection
PDF Full-text Download PDF Full-Text [165 KB, uploaded 19 June 2014 04:30 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Gu, A.-D.; Zeng, M.-S.; Qian, C.-N. The Criteria to Confirm the Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma Initiation. Int. J. Mol. Sci. 2012, 13, 13737-13747.

AMA Style

Gu A-D, Zeng M-S, Qian C-N. The Criteria to Confirm the Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma Initiation. International Journal of Molecular Sciences. 2012; 13(10):13737-13747.

Chicago/Turabian Style

Gu, Ai-Di; Zeng, Mu-Sheng; Qian, Chao-Nan. 2012. "The Criteria to Confirm the Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma Initiation." Int. J. Mol. Sci. 13, no. 10: 13737-13747.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert