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Int. J. Mol. Sci. 2012, 13(10), 12710-12733; doi:10.3390/ijms131012710
Review

Crossing Paths in Human Renal Cell Carcinoma (hRCC)

1
, 1,* , 2
, 1
 and 3,4
Received: 26 July 2012; in revised form: 11 September 2012 / Accepted: 26 September 2012 / Published: 5 October 2012
(This article belongs to the Section Molecular Pathology)
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Abstract: Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence supports the fact that intracellular drivers of tumor progression do not flow in a single linear pathway, but disseminate into multiple intracellular pathways. An improved understanding of the complexity of cancer depends on the elucidation of the underlying regulatory networks at the cellular and intercellular levels and in their temporal dimension. The high complexity of the intracellular cascades causes the complete inhibition of the growth of one tumor cell to be very unlikely, except in cases in which the so-called “oncogene addiction” is known to be a clear trigger for tumor catastrophe, such as in the case of gastrointestinal stromal tumors or chronic myeloid leukemia. In other words, the separation and isolation of the driver from the passengers is required to improve accuracy in cancer treatment. This review will summarize the signaling pathway crossroads that govern renal cell carcinoma proliferation and the emerging understanding of how these pathways facilitate tumor escape. We outline the available evidence supporting the putative links between different signaling pathways and how they may influence tumor proliferation, differentiation, apoptosis, angiogenesis, metabolism and invasiveness. The conclusion is that tumor cells may generate their own crossroads/crosstalk among signaling pathways, thereby reducing their dependence on stimulation of their physiologic pathways.
Keywords: human renal cell carcinoma (hRCC); signaling pathway crosstalk; biomarkers human renal cell carcinoma (hRCC); signaling pathway crosstalk; biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gallego, G.A.; Villaamil, V.M.; Grande, E.; Caínzos, I.S.; Aparicio, L.M.A. Crossing Paths in Human Renal Cell Carcinoma (hRCC). Int. J. Mol. Sci. 2012, 13, 12710-12733.

AMA Style

Gallego GA, Villaamil VM, Grande E, Caínzos IS, Aparicio LMA. Crossing Paths in Human Renal Cell Carcinoma (hRCC). International Journal of Molecular Sciences. 2012; 13(10):12710-12733.

Chicago/Turabian Style

Gallego, Guadalupe A.; Villaamil, Vanessa M.; Grande, Enrique; Caínzos, Isabel S.; Aparicio, Luís M.A. 2012. "Crossing Paths in Human Renal Cell Carcinoma (hRCC)." Int. J. Mol. Sci. 13, no. 10: 12710-12733.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert