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Int. J. Mol. Sci. 2012, 13(10), 12544-12555; doi:10.3390/ijms131012544

MicroRNAs as Diagnostic Biomarkers in Gastric Cancer

Institute of Clinical Research of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, China
Author to whom correspondence should be addressed.
Received: 24 July 2012 / Revised: 31 August 2012 / Accepted: 5 September 2012 / Published: 1 October 2012
(This article belongs to the Special Issue Advances in Molecular Oncology (special issue))
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Considering the high mortality rates and the unfavorable prognosis of gastric cancer (GC) as well as the lack of a clinical predictive marker, which is sufficiently sensitive to GC, it is of great significance to investigate new sensitive and specific markers for GC diagnosis. MicroRNAs (miRNAs) could be a practical form of potential biomarkers in the diagnosis of human disease, and they are confirmed to be closely associated with GC. In this review, we discuss the recent research results that indicate the feasibility and clinical applications of miRNAs in GC. Although several challenges remain to be addressed, miRNAs have the potential to be applied in the diagnosis of GC.
Keywords: microRNAs; gastric cancer; biomarkers; diagnosis microRNAs; gastric cancer; biomarkers; diagnosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yin, Y.; Li, J.; Chen, S.; Zhou, T.; Si, J. MicroRNAs as Diagnostic Biomarkers in Gastric Cancer. Int. J. Mol. Sci. 2012, 13, 12544-12555.

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