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• Yin, Y
• Li, J
• Chen, S
• Zhou, T
• Si, J
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• Li, J
• Chen, S
• Zhou, T
• Si, J
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• Li, J
• Chen, S
• Zhou, T
• Si, J

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Int. J. Mol. Sci. 2012, 13(10), 12544-12555; doi:10.3390/ijms131012544

Review

MicroRNAs as Diagnostic Biomarkers in Gastric Cancer

Ying Yin, Jun Li, Shujie Chen, Tianhua Zhou and Jianmin Si*

Institute of Clinical Research of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, China

* Author to whom correspondence should be addressed.

Received: 24 July 2012; in revised form: 31 August 2012 / Accepted: 5 September 2012 / Published: 1 October 2012

(This article belongs to the Special Issue Advances in Molecular Oncology)

Download PDF Full-Text [183 KB, uploaded 1 October 2012 10:48 CEST]

Abstract: Considering the high mortality rates and the unfavorable prognosis of gastric cancer (GC) as well as the lack of a clinical predictive marker, which is sufficiently sensitive to GC, it is of great significance to investigate new sensitive and specific markers for GC diagnosis. MicroRNAs (miRNAs) could be a practical form of potential biomarkers in the diagnosis of human disease, and they are confirmed to be closely associated with GC. In this review, we discuss the recent research results that indicate the feasibility and clinical applications of miRNAs in GC. Although several challenges remain to be addressed, miRNAs have the potential to be applied in the diagnosis of GC.

Keywords: microRNAs; gastric cancer; biomarkers; diagnosis

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