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Phosphoproteomics and Lung Cancer Research
Hospital Universitario Niño Jesús, Department of Oncohematology of Children, Madrid 28009, Spain
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
* Author to whom correspondence should be addressed.
Received: 8 August 2012; in revised form: 14 September 2012 / Accepted: 19 September 2012 / Published: 26 September 2012
Abstract: Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease. It is imperative to search these biomarkers in different tumorigenesis pathways so as to provide the most appropriate therapy for each individual patient with lung malignancy. Phosphoproteomics is a promising technology for the identification of biomarkers and novel therapeutic targets for cancer. Thousands of proteins interact via physical and chemical association. Moreover, some proteins can covalently modify other proteins post-translationally. These post-translational modifications ultimately give rise to the emergent functions of cells in sequence, space and time. Phosphoproteomics clinical researches imply the comprehensive analysis of the proteins that are expressed in cells or tissues and can be employed at different stages. In addition, understanding the functions of phosphorylated proteins requires the study of proteomes as linked systems rather than collections of individual protein molecules. In fact, proteomics approaches coupled with affinity chromatography strategies followed by mass spectrometry have been used to elucidate relevant biological questions. This article will discuss the relevant clues of post-translational modifications, phosphorylated proteins, and useful proteomics approaches to identify molecular cancer signatures. The recent progress in phosphoproteomics research in lung cancer will be also discussed.
Keywords: lung cancer; mass spectrometry; phosphoproteomics; post-translational modification; signaling pathway
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López, E.; Cho, W.C.S. Phosphoproteomics and Lung Cancer Research. Int. J. Mol. Sci. 2012, 13, 12287-12314.
López E, Cho WCS. Phosphoproteomics and Lung Cancer Research. International Journal of Molecular Sciences. 2012; 13(10):12287-12314.
López, Elena; Cho, William C. S. 2012. "Phosphoproteomics and Lung Cancer Research." Int. J. Mol. Sci. 13, no. 10: 12287-12314.