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The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats
Division of Traumatology, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan
Department of Sports Management, College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan
Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
* Author to whom correspondence should be addressed.
Received: 13 August 2012; in revised form: 3 September 2012 / Accepted: 17 September 2012 / Published: 25 September 2012
Abstract: Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 ´ 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.
Keywords: abdominal; adhesions; hyperbaric oxygen (HBO); rats
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MDPI and ACS Style
Chen, M.-J.; Chen, T.-Y.; Cheng, Y.-M.; Hsu, Y.-C. The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats. Int. J. Mol. Sci. 2012, 13, 12224-12231.
Chen M-J, Chen T-Y, Cheng Y-M, Hsu Y-C. The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats. International Journal of Molecular Sciences. 2012; 13(10):12224-12231.
Chen, Ming-Jenn; Chen, Tzu-Yu; Cheng, Ya-Min; Hsu, Yi-Chiang. 2012. "The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats." Int. J. Mol. Sci. 13, no. 10: 12224-12231.