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Int. J. Mol. Sci. 2012, 13(10), 12224-12231; doi:10.3390/ijms131012224
Article

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

1,2
, 3,4
, 5
 and 3,4,*
Received: 13 August 2012; in revised form: 3 September 2012 / Accepted: 17 September 2012 / Published: 25 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 ´ 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.
Keywords: abdominal; adhesions; hyperbaric oxygen (HBO); rats abdominal; adhesions; hyperbaric oxygen (HBO); rats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, M.-J.; Chen, T.-Y.; Cheng, Y.-M.; Hsu, Y.-C. The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats. Int. J. Mol. Sci. 2012, 13, 12224-12231.

AMA Style

Chen M-J, Chen T-Y, Cheng Y-M, Hsu Y-C. The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats. International Journal of Molecular Sciences. 2012; 13(10):12224-12231.

Chicago/Turabian Style

Chen, Ming-Jenn; Chen, Tzu-Yu; Cheng, Ya-Min; Hsu, Yi-Chiang. 2012. "The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats." Int. J. Mol. Sci. 13, no. 10: 12224-12231.



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