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Int. J. Mol. Sci. 2012, 13(1), 336-347; doi:10.3390/ijms13010336
Article

Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment

1,* , 2
 and 1
1 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia 2 Department of Biotechnology, Faculty of Applied Sciences, Asian Institute of Medicine, Science and Technology, 08000 Sungai Petani, Kedah, Malaysia
* Author to whom correspondence should be addressed.
Received: 21 July 2011 / Revised: 2 November 2011 / Accepted: 28 November 2011 / Published: 28 December 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.
Keywords: Elaeis guineensis; wound healing activity; matrix metalloproteinases; gelatin zymography Elaeis guineensis; wound healing activity; matrix metalloproteinases; gelatin zymography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sasidharan, S.; Logeswaran, S.; Latha, L.Y. Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment. Int. J. Mol. Sci. 2012, 13, 336-347.

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